Protatranes, effective growth biostimulants of hydrocarbon-oxidizing bacteria from Lake Baikal, Russia.

Under natural conditions, biodegradation processes proceed slowly, especially in regions with low temperature. To activate vital processes in hydrocarbon-oxidizing microorganisms at low temperatures, biologically active compounds can be employed as growth stimulants. A low-temperature (10 °C) study has shown that tris-(2 hydroxyethyl) ammonium arylchalcogenylacetates, "protatranes" exert an effect on the growth of hydrocarbon-oxidizing strains of and , isolated from natural oil seepage on Lake Baikal.

Reaction of pharmacological active tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate with ZnCl2 or NiCl2: first conversion of a protic ionic liquid into metallated ionic liquid.

The reaction of pharmacological active protic ionic liquid tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate H+N(CH2CH2OH)3 ∙ (-OOCCH2SC6H4Cl-4) (1) with zinc or nickel chloride in a ratio of 2:1 affords stable at room temperature powder-like adducts [H+N(CH2CH2OH)3]2 ∙ [M(OOCCH2SC6H4Cl-4)2Cl2]2-, M = Zn (2), Ni (3). By recrystallization from aqueous alcohol compound 2 unexpectedly gives Zn(OOCCH2SC6H4Cl-4)2 ∙ 2H2O (4). Unlike 2, compound 3 gives crystals [N(CH2CH2OH)3]2Ni2+ · [-OOCCH2SC6H4Cl-4]2 (5), which have a structure of metallated ionic liquid.

Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate).

The title compound was prepared by the reaction of 1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane with 4-chloro-2-methyl-phenoxyacetic acid in a ratio of 1:2. The structure has been proved by the data of elemental analysis, IR spectroscopy, NMR (1H, 13C) technique and by X-ray diffraction analysis. Intermolecular hydrogen bonds between the azonium protons and oxygen atoms of the carboxylate groups were found.

[Screening of new derivatives of arylheteroalkanecarboxylic acid on the immune system].

The screening of 13 original compounds from the group of derivatives of arylheteroalkanecarboxylic acid on immunity were performed. The compounds exhibit strong myelostimulating/myelosuppressive property, increased or decreased influence on the: PFC (IgM and IgG), DTH at the sheep erythrocytes in CBF1 in vivo. In contrast, in vitro the compounds had no effect or inhibited the spontaneous, ConA or PWM induced proliferation of the splenocytes from normal mice.

[The immunoactive properties of trekrezan].

It was shown that in vivo trecrezan possessed strong immunoactive properties: it decreased the spot-forming activity of polypotent stem blood cells, stimulated lympho- and hemopoesis, antibody formation, possessed steady antiinflammatory activity. It stimulated in vitro mononuclear cell proliferation in man due to its direct action on B lymphocytes and increase in lymphokine and monokine production.

[Effect of Bacillus mucilaginosus biomass on the exocrine function of the pancreas in piglets].

The effect of mucous bacilli on the excretory activity of pancreas in pigs has been investigated. The use of biomass at doses of 0.1, 0.

[Antibacterial and antiviral activity of the polychloroethyl- and beta,beta-dichlorovinylamides of carboxylic acids].

A number of compounds having antiviral and antibacterial (antistaphylococcal) activity was found in the beta,beta-dichlorvinyl- and alpha-chlor(alpha-oxy)-beta,beta,beta-trichlorethylamide series of carboxylic acids. The antistaphylococcal activity of the compounds under study was found to depend, to a certain extent, ontheir chemical structure, whereas no such dependence was established in respect of their antiviral activity. In the treatment of combined influenza-staphylococcal infection a decrease in antistaphylococcal effect was observed, while antiviral activity remained stable.

[Antibacterial and antiviral activity of beta,beta-dichlorvinylpyrrolidone].

Antiviral and antibacterial activity of chlorine-containing N-vinylpyrrholidon analogue - beta,beta-dichlorvinylpyrrholidon (first synthesized in 1970) was studied on a model of influenza A2 virus. Peculiarities of the influence of beta,beta-dichlorvinylpyrrholidon on the reproduction of microbial and viral agents under conditions of their isolated and combined cultivation were revealed.