Publications by authors named "Mirrah Bashir"
Article Synopsis
- Intrauterine growth restriction (IUGR) combined with oxygen exposure negatively impacts brain development, increasing the risk of neurodevelopmental disabilities such as cerebral palsy.
- Research using mouse models revealed that both conditions alter gene expression, with IUGR/hyperoxia leading to significant downregulation of myelination-related genes.
- The study highlights specific gene regulators involved in these changes, aiming to identify therapeutic targets and improve outcomes for infants affected by IUGR and oxygen exposure.
Intrauterine growth restriction (IUGR) is estimated to occur in 5% of pregnancies, with placental insufficiency being the most common cause in developed countries. While it is known that white matter injury occurs in premature infants, the extent of IUGR on white matter injury is less defined in term infants. We used a novel murine model that utilizes a thromboxane A2 (TXA2) analog (U46619), a potent vasoconstrictor, to induce maternal hypertension and mimic human placental insufficiency-induced IUGR to study the white matter.
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