Publications by authors named "Miroslavov A"

Technetium(I) 2 + 1 tricarbonyl complexes with a combination of ,-bidentate ligands (2,2'-bipyridine, bipy; 1,10-phenanthroline, phen) and ethyl isocyanoacetate were prepared and characterized by NMR, IR, UV/visible, and luminescence spectroscopies and by high-performance liquid chromatography (HPLC). The crystal structures of [Tc(CO)(bipy)(CNCHCOOEt)](ClO) (in the form of a solvate with 0.5CHCl) and [Tc(CO)(phen)(CNCHCOOEt)](ClO) (in the form of an adduct with an outer-sphere phen molecule) were determined by single-crystal X-ray diffraction.

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Reaction of [Tc(CO)]ClO with alkali in aqueous solutions yields yellow TcH(CO) as the major product. On the other hand, [TcH(CO)] becomes the major product when the reaction with alkali is combined with the extraction into hexane. The molecular structure of TcH(CO), determined by SCXRD, is composed of the Tc(CO) fragment bound to the Tc(CO) fragment via the hydrogen bridge and weak metal-metal bond.

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Technetium pentacarbonyl fluoride [TcF(CO)5] was prepared for the first time by reaction of [TcI(CO)5] with solid AgF in a dichloromethane solution at -23 °C. Low temperature crystallization of the resulting compound in a glass vial yielded an unusual complex [Tc(CO)3(OH)0.49F0.

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Technetium(I) and rhenium(I) pentacarbonyl complexes with ethyl 2-isocyanoacetate and methyl 11-isocyanoundecanoate, [M(CO)5(CNCH2COOEt)]ClO4 (M = Tc (1) and Re (2)) and [M(CO)5(CN(CH2)10COOMe)]ClO4 (M = Tc (3) and Re (4)), were prepared and characterized by IR, (1)H NMR, and (13)C{(1)H} NMR spectroscopy. The crystal structures of 1 and 2 were determined using single-crystal X-ray diffraction. The kinetics of thermal decarbonylation of technetium complexes 1 and 3 in ethylene glycol was studied by IR spectroscopy.

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Myocardial perfusion imaging is an established Nuclear Medicine investigation. Current myocardial perfusion imaging agents sestamibi and tetrofosmin have number of drawbacks; low heart uptake coupled with uptake into the surrounding tissues leads to a poorer image quality. There is a need for continued research into designing and evaluating potentially superior myocardial imaging agents.

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Technetium(I) tetracarbonyl complexes with diethyldithiocarbamate and methylxanthate ligands [TcL(CO)(4)] (L = S(2)CNEt(2) and S(2)COMe) were prepared. Conditions required for the formation of these complexes were found. The crystal and molecular structure of the xanthate complex was determined by single-crystal X-ray diffraction.

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Introduction: The use of (99m)Tc-macroggregated albumin for lung perfusion imaging is well established in nuclear medicine. However, there have been safety concerns over the use of blood-derived products because of potential contamination by infective agents, for example, Variant Creutzfeldt Jakob Disease. Preliminary work has indicated that Tc(CO)(5)I is primarily taken up in the lungs following intravenous administration.

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The title compound, [Tc(CO)(6)]ClO(4), was synthesized by the reaction of [TcCl(CO)(5)] with AgClO(4), followed by acidification with HClO(4) under a CO atmosphere. The [Tc(CO)(6)](+) cation has close to idealized octa-hedral geometry, with the bond angles between cis-CO groups close to 90° and the Tc-C bond lengths in the range 2.025 (3)-2.

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