Publications by authors named "Miroslava Nunez-Aguirre"

Background: Currently, there is scant information regarding the features associated to the persistence of post-COVID-19 syndrome, which is the main aim of the present study.

Methods: A cohort study of 102 COVID-19 patients was conducted. The post-COVID-19 symptoms were assessed by a standardised questionnaire.

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Article Synopsis
  • Research on long-term antibody responses to COVID-19 focused on anti-SARS-CoV-2 IgG titers without considering patients' baseline immune profiles, which may affect antibody responses.
  • The study followed 103 COVID-19 patients, assessing their immune profiles and antibody levels at multiple time points over six months to identify factors linked to sustained immunity.
  • Findings indicated that critical illness status and certain immune factors at baseline were significantly associated with a prolonged immune response, highlighting the importance of early immune characteristics in recovery.
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  • COVID-19 is linked to increased production of neutrophil extracellular traps (NETs) and associated autoimmune responses, particularly in severe cases.
  • The study found that patients with severe/critical COVID-19 had a higher proportion of low-density granulocytes (LDGs) and reduced capacity to degrade NETs, which were connected to the severity of the disease and inflammatory markers.
  • Anti-NET antibodies were identified in COVID-19 patients, correlating with the presence of other autoantibodies, indicating that NETs may drive both inflammation and potential autoimmune reactions.
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  • This study aims to identify new biological factors that explain the severity and prognosis of COVID-19, addressing the gaps in existing models.
  • Researchers developed a predictive model for COVID-19 severity using data from 121 patients, analyzing various clinical and biological traits, achieving a high accuracy rate.
  • Key findings include significant variables such as BMI, specific immune cells, and various metabolites, revealing how immune response and inflammation contribute to disease severity and outcomes.
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