Publications by authors named "Miroslava K Adamcova"
ORMDL3 is a prominent member of a family of highly conserved endoplasmic reticulum resident proteins, ORMs (ORM1 and ORM2) in yeast, dORMDL in and ORMDLs (ORMDL1, ORMDL2, and ORMDL3) in mammals. ORMDL3 mediates feedback inhibition of sphingolipid synthesis. Expression levels of ORMDL3 are associated with the development of inflammatory and autoimmune diseases including asthma, systemic lupus erythematosus, type 1 diabetes mellitus and others.
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- * Using a mouse model of chronic multifocal osteomyelitis (CMO), researchers found that both hematopoietic and nonhematopoietic components in the bone marrow (BM) promote HSC growth but diminish their functionality.
- * The study highlighted that the CMO environment alters HSCs to adopt a pro-inflammatory profile through IL-6 and the Jak/Stat3 signaling pathway; targeting Stat3 showed promise in improving HSC function, indicating potential new treatment avenues for chronic inflammation
Hematopoietic stem cell transplantation (HSCT) is a frequent therapeutic approach to restore hematopoiesis in patients with hematologic diseases. Patients receive a hematopoietic stem cell (HSC)-enriched donor cell infusion also containing immune cells, which may have a beneficial effect by eliminating residual neoplastic cells. However, the effect that donor innate immune cells may have on the donor HSCs has not been deeply explored.
View Article and Find Full Text PDFDeferoxamine (DFO) represents a widely used iron chelator for the treatment of iron overload. Here we describe the use of mitochondrially targeted deferoxamine (mitoDFO) as a novel approach to preferentially target cancer cells. The agent showed marked cytostatic, cytotoxic, and migrastatic properties , and it significantly suppressed tumor growth and metastasis .
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