Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated -Fusion Positive Pediatric High-Grade Glioma.

Targeting oncogenic fusion-genes in pediatric high-grade gliomas (pHGG) with entrectinib has emerged as a highly promising therapeutic approach. Despite ongoing clinical studies, to date, no reports on the treatment of cerebrospinal fluid (CSF) disseminated fusion-positive pHGG exist. Moreover, clinically important information of combination with other treatment modalities such as intrathecal therapy, radiotherapy and other targeted agents is missing.

Technetium-99m-tetrofosmin in diagnosis of breast cancer and axillary lymph node involvement.

Background: The aim of this study was to evaluate the accuracy of breast cancer seeking agent Tc-99m-Tetrofosmin in the detection of breast malignancy and axillary lymph node metastases.

Material And Methods: Twenty-eight female patients (mean age 52.4) with 30 breast lesions suspected of malignancy were enrolled in the study.

[Breast carcinoma with melanocytic differentiation].

Azzopardi and Eusebi were the first to describe pigmented breast cancers in 1977. They postulated that the mammary cancer might become colonized by melanocytes at the expense of the epidermis, which was focally depleted of melanocytes, and that it occurred in most cases of breast cancers in which tumor cells reached the dermal-epidermal interface. Other authors suggested melanocytic differentiation of tumor cells.

[Diagnosis of the Mikulicz-Sjogren syndrome using biopsy of the minor salivary glands].

Background: Sjögren's syndrome (SS) represents autoimmune disease characterized by chronic inflammation, destruction and insufficiency of exocrine glands, particularly salivary and lacrimal glands, accompanied by dryness of mouths and eyes. Diagnostic work-up involves clinical laboratory tests, radiography, scintigraphy and bioptic histopathological examination. Examination of small salivary glands in the biopsy of the lower lip represents a "golden standard" of diagnosis of SS, concerning the fact that the growth and the disfunction of salivary and lacrimal glands occurs in different pathologic states.