Lack of omalizumab efficacy in severe atopic dermatitis with extremely elevated IgE levels: two case reports and a literature review.

The authors present two cases of severe atopic dermatitis with extremely elevated IgE levels treated with omalizumab. The effect of this treatment was completely unconvincing in both patients, most likely because of extremely elevated IgE values, which could not be eliminated by omalizumab. Our observation is consistent with earlier published literature reporting that omalizumab as a treatment for atopic dermatitis seems to work better in patients with lower levels of IgE antibodies.

Atopy patch testing with airborne allergens.

Introduction: Atopy patch tests (APT) represent a relatively new diagnostic method for identifying the role of airborne allergens in atopic dermatitis flares. This study evaluates the role of airborne allergens in atopic dermatitis flares in a group of adult patients with atopic dermatitis. The primary goal was to detect the frequency of sensitization to these allergens in a group of patients with atopic dermatitis by APT.

Ustekinumab in the treatment of severe rupioid psoriasis: A case report.

This paper describes a case of a patient with widespread rupioid psoriasis in whom ustekinumab was introduced because of a relative contraindication to conventional systemic treatment and insufficient effect of phototherapy. Improvement of his psoriasis was very rapid, with a decrease in the PASI of 63.4% (from 30.

Matrix metalloproteinase-2 promoter genotype as a marker of cutaneous T-cell lymphoma early stage.

The aim of the study was to investigate the DNA polymorphic genotype in MMP-2 promoter gene as a potential candidate region for the development of the cutaneous T-cell lymphoma (CTCL) and/or its progression. A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls of similar age and sex distribution, without personal or family history of chronic skin diseases and without personal history of malignancy. The three selected polymorphisms in the promoter of MMP-2 gene (-1575G/A, -1306C/T, and -790T/G) were determined using the PCR-based methodology with RFLP.

MTHFR (methylenetetrahydrofolate reductase) C677T polymorphism and psoriasis.

The aim of the study was to evaluate possible association of MTHFR C677T gene polymorphism (NM_005957) with psoriasis. Genotypes of MTHFR C677T gene polymorphism were determined in a sample of 654 Caucasian (Czech) subjects. Case group (n = 410) included patients with psoriasis (plaque psoriasis diagnosed in 285 patients, other subtypes of psoriasis were observed in 125 patients).

Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema.

Objective: 1) Assessment of the frequency of contact sensitization to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. 2) Detection of the sources of sensitization.

Methods: 1,927 patients with chronic eczema (mean age 44.

Pyoderma gangraenosum associated with autoimmune thyreopathy and hyperandrogenic syndrome.

An unusual clinical appearance and course of pyoderma gangraenosum (PG) in a 35-year-old woman is presented. Signs of both the ulcerative and vegetative forms of PG were expressed. The association of two systemic diseases, the autoimmune thyreopathy and the hyperandrogenic syndrome were observed in a female.