Publications by Miroslav Lech

Publications by authors named "Miroslav Lech"

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Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis.

Sassan HajMohammadi Keiichi Enjyoji Marc Princivalle Patricia Christi Miroslav Lech

J Clin Invest

April 2003

Endothelial cell production of anticoagulant heparan sulfate (HS(act)) is controlled by the Hs3st1 gene, which encodes the rate-limiting enzyme heparan sulfate 3-O-sulfotransferase-1 (3-OST-1). In vitro, HS(act) dramatically enhances the neutralization of coagulation proteases by antithrombin. The in vivo role of HS(act) was evaluated by generating Hs3st1(-/-) knockout mice.

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