[Case of giant cell myocarditis].

A case of giant cell myocarditis with atrioventricular blockade and progressive cardiac insufficiency is reported that required implantation of an artificial pacemaker and ended in the death of the patient. The diagnosis was confirmed by a histological study following autopsy. The difficulty of diagnosis of this rare form of myocarditis with an aggressive clinical course is emphasized.

[Effect of delayed coronary angioplasty after thrombolytic therapy on outcome of acute myocardial infarction].

Patients with acute myocardial infarction (n=161) were in random order divided into 2 groups: (1) those who received thrombolytic therapy (TT), (n=126), (2) those who received TT, optimized coronary angioplasty (TT+CA) on days 2-7 (n=35). During hospital period we assessed systolic and diastolic left ventricular (LV) function, content of cytokine tumor necrosis factor a (TNF a) and its soluble receptor type I (sTNF alphaR-I). Outcomes were registered after 1 year.

[Kordaron and functional disorders of the thyroid gland].

The paper presents a brief review of literature data on cordaron action on thyroid function under a prolonged schedule of its use, and a description of 4 cases of thyrotoxicosis developed by males after 2-10 years of cordaron maintenance for paroxysms of cardiac fibrillation in a dose of 200-600 mg. Probability of thyrotoxicosis necessitates an assessment of thyroid function when planning long-term treatment with cordaron.

[Distribution in mice of 125I-monoclonal antibodies to T-lymphocyte antigen Ly 2.1 under the influence of immunomodulators].

A study was made of the distribution of 125I (a chloramine method of labeling) monoclonal antibodies to the surface antigen Ly 2.1 of T-lymphocytes during action of immunomodulators (tactivin, hydrocortisone, tactivin administered after hydrocortisone) on ACR mice. These antibodies were shown to retain antigen binding capacity, permitting monitoring of the redistribution of the antigen in the body exposed to immunomodulators.

[The distribution of 125I-monoclonal antibodies to Bence Jones proteins in the body of animals].

A study was made of the biodistribution of 125I-labeled (chloramine, lactoperoxidase and iodogen tracer methods) monoclonal antibodies to free lambda and kappa chains of human immunoglobulins (Bence Jones proteins) using experimental models: ACR mice with a depot of antigen in the muscular tissue. Labeled MAB were shown to preserve their immunological properties. The results of investigation into biodistribution helped to reveal selective accumulation of radioactivity in the antigen depot (Bence Jones protein).