Publications by authors named "Mirlind Zaganjori"
Aim: Standardized evaluation of [F]PI-2620 tau-PET scans in 4R-tauopathies represents an unmet need in clinical practice. This study aims to investigate the effectiveness of visual evaluation of [F]PI-2620 images for diagnosing 4R-tauopathies and to develop a straight-forward reading algorithm to improve objectivity and data reproducibility.
Methods: A total of 83 individuals with [F]PI-2620 PET scans were included.
Introduction: Recent advances in biomarker research have improved the diagnosis and monitoring of Alzheimer's disease (AD), but in vivo biomarker-based workflows to assess 4R-tauopathy (4RT) patients are currently missing. We suggest a novel biomarker-based algorithm to characterize AD and 4RTs.
Methods: We cross-sectionally assessed combinations of cerebrospinal fluid measures (CSF p-tau and t-tau) and F-PI-2620 tau-positron emission tomography (PET) in patients with AD (n = 64), clinically suspected 4RTs (progressive supranuclear palsy or corticobasal syndrome, n = 82) and healthy controls (n = 19).
Article Synopsis
- Four-repeat tauopathies are brain diseases that happen when a protein called 4R tau builds up in certain areas of the brain, affecting how it works.
- Two main types of these diseases are progressive supranuclear palsy (PSP) and corticobasal degeneration, which both cause problems in brain regions that are important for movement and other functions.
- The researchers are trying to figure out how the problems in one part of the brain (subcortical) affect other connected areas (cortical) by studying patients and using special brain scans to see how these changes relate to each other.
Article Synopsis
- Postural instability in progressive supranuclear palsy (PSP) may result from abnormal vestibulospinal reflexes, and low-intensity noisy galvanic vestibular stimulation (nGVS) has been investigated as a non-invasive treatment to improve balance.* -
- In a study with 16 PSP patients, nGVS at various intensities was tested for its effects on body sway, specifically looking for a bell-shaped response curve indicative of stochastic resonance (SR).* -
- Results showed that nGVS significantly reduced body sway in 56% of patients, with some experiencing improvements that were clinically meaningful, suggesting nGVS could be an effective strategy for managing postural symptoms in PSP.*
Purpose: [F]PI-2620 positron emission tomography (PET) detects misfolded tau in progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). We questioned the feasibility and value of absolute [F]PI-2620 PET quantification for assessing tau by regional distribution volumes (V). Here, arterial input functions (AIF) represent the gold standard, but cannot be applied in routine clinical practice, whereas image-derived input functions (IDIF) represent a non-invasive alternative.
View Article and Find Full Text PDFBackground And Objectives: 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation in Alzheimer's disease (AD) research. Sex and obesity effects on TSPO-PET binding have been reported for cognitively normal humans (CN), but such effects have not yet been systematically evaluated in patients with AD. Thus, we aimed to investigate the impact of sex and obesity on the relationship between β-amyloid-accumulation and microglial activation in AD.
View Article and Find Full Text PDFβ-amyloid (Aβ) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer's disease (AD), and biomarkers for these hallmarks have been linked to neuroinflammation. However, the detailed regional associations of these biomarkers with microglial activation in individual patients remain to be elucidated. We investigated a cohort of 55 patients with AD and primary tauopathies and 10 healthy controls that underwent TSPO-, Aβ-, tau-, and perfusion-surrogate-PET, as well as structural MRI.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how microglial activation, which is linked to neuroinflammation in Alzheimer's disease (AD), relates to the connectivity of brain regions in Aβ-positive early AD patients compared to healthy controls.
- - Utilizing advanced imaging techniques like positron emission tomography (PET) and magnetic resonance imaging (MRI), researchers found that microglial activation was more prominent in functionally connected brain areas in AD patients, correlating with cognitive decline.
- - The findings suggest that, similar to tau pathology, microglial activation spreads along highly interconnected brain pathways, highlighting its potential role in the progression of neurodegeneration in AD.