Publications by authors named "Mirla Borghi"
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) represents an urgent threat to global public health due to the limited therapeutic options available to control this pathogen. This study aims to analyze the molecular epidemiology, antimicrobial resistance and virulence profile of CRKP isolated from patients at hospitals in Southeastern Brazil. KPC and other beta-lactamase genes were detected in all strains, which were also multidrug-resistant (MDR).
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- Enzymes from the OXA-48 family, essential beta-lactamases, are increasingly important, with a new variant (OXA-370) first identified in Brazil in 2013.
- In a study from 2013-2014, the blaOXA-370 gene was detected in 24 Enterobacteriaceae isolates across five hospitals in Rio de Janeiro, showing a multidrug resistance profile, including resistance to polymyxin B in some cases.
- Molecular typing revealed that Klebsiella pneumoniae isolates belonged to two clonal groups, with the predominant one (ST16) linked to previous KPC-producing strains, indicating a need for further investigation into the spread of this resistance in Brazil.
The most important resistance mechanism against β-lactam drugs is the production of carbapenemases. In this study, we report the first identification of Klebsiella pneumoniae carbapenemase (KPC)-2 and New Delhi metallo-β-lactamase (NDM)-1 in Enterobacter hormaechei subps. oharae from Brazil.
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