Altered fibrin-clot properties are associated with retinopathy in type 2 diabetes mellitus.

Aim: The development and progression of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) have been associated with poor glycaemic control, long disease duration and other clinical features. However, the pathogenesis of the complication is still poorly understood. As the formation of dense fibrin clots resistant to lysis has been described in diabetes patients, this study tested the hypothesis that altered clot structure and function are associated with DR in T2DM patients.

Efficacy and safety of sulfonylurea use in permanent neonatal diabetes due to KCNJ11 gene mutations: 34-month median follow-up.

Background: Recently, many patients with Kir6.2-related permanent neonatal diabetes mellitus (PNDM) have been successfully transferred from insulin therapy to sulfonylurea (SU) treatment. The long-term efficacy and safety of SU treatment in PNDM patients, however, have not yet been determined.

Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction.

Background: Microangioathy and macroangiopathy in type 2 diabetes mellitus (T2DM) frequently coexist. Both types of vascular complications share traditional risk factors. It is not clear whether the presence of microangiopathy, such as diabetic retinopathy (DR), constitutes a predictor of atherosclerosis in T2DM.

Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes.

Objective: Molecular background of diabetic retinopathy (DR) remains unknown. An interesting group of candidate genes encode proteins involved in insulin resistance.

Aim: To search for association between the PPARgamma, calpain 10, PTPN1 genes and DR in type 2 diabetes mellitus (T2DM).

Clinical risk factors and the role of VDR gene polymorphisms in diabetic retinopathy in Polish type 2 diabetes patients.

Evidence exists that some clinical, metabolic and genetic risk factors are associated with the development of diabetic retinopathy (DR). The aim of the study was: (1) to define the prevalence of DR in the examined group of 267 patients with type 2 diabetes mellitus (T2DM) from a Polish population; (2) to identify in cross-sectional analysis, the clinical features associated with DR in the study group; and (3) to search for the association of 4 markers of vitamin D receptor (VDR), a candidate gene for vascular complications in diabetes, with DR. The examined group consisted of 146 female and 121 male T2DM patients (mean age at examination: 61.

[Traumatic cataract--treatment results].

Purpose: The aim of the study was to analyse late results of treating patients with cataract, due to blunt and perforating trauma. Analysis included factors related to type of treatment, time from the trauma to surgery, frequency and type of complications.

Material And Methods: The study population consisted of 60 patients, 56 men aged from 13 to 76 years (mean age 39.

[Risk factors for occurrence of ophthalmopathy in the course of Graves-Basedow disease].

Ophthalmopathy is a serious complication of Graves-Basedow disease. It is a common and the most significant symptom of this illness and usually persists even when other symptoms associated with abnormal thyroid function disappear. Despite of well-known auto-immunologic patho-genesis of ophthalmopathy it is still hard to predict when this severe complication will occur.

[Ophthalmologic aspects of treating optic neuropathy during the course of Graves-Basedow disease].

Unlabelled: The aim of the present study is to evaluate the efficacy of conservative treatment of optic neuropathy in the course of Graves' disease. Nineteen patients with neuropathy out of 520 patients with Graves' disease, including 15 women and 4 men were treated. Age of the patients ranged from 36 to 69 years, mean age was 51.

[Surgical correction of strabismus in Graves-Basedow ophthalmopathy. Personal experiences].

Unlabelled: The aim of the study was to evaluate long-term results of surgical treatment of strabismus and diplopia connected with Graves' ophthalmopathy. Surgery of extraocular muscles was performed in 64 patients, previously with different methods for their Graves' ophthalmopathy. All patients showed stabilization of the strabismus angle and diplopia as well as euthyroidism.

[Graves-Basedow ophthalmopathy in light of current views].

Ophthalmopathy developing in the course of Graves-Basedow disease, although known for years, still causes controversy both about classification of eye symptoms, treatment modalities and terminology. The paper gives an update view on the etiopathogenesis of ophthalmopathy, terminology, classification and dynamics of clinical symptoms, as well as it presents the methods for treating its most important symptoms. Particular attention was focused on surgical treatment of lid retraction and strabismus, as well as on the present requirements in pharmacological and surgical treatment of the most serious complication of ophthalmopathy i.

[Attempts of orbit irradiation after enucleation of the eye with malignant choroidal melanoma. Part I].

Purpose: The problem of orbit irradiation after enucleation of the eye with choroidal melanoma is controversial. We have decided to analyse our own material in order to estimate the effectiveness of this method.

Material And Methods: The clinical material comprised 202 patients, 97 women and 105 men, in the age of 15-84 years, whose eyeballs were enucleated because of choroidal melanoma.

[Scleritis resembling choroidal melanoma: a case report].

The clinical manifestations of the disease, its course and response to the therapy were typical of the inflammatory state in the eye. However, magnetic resonance imaging suggested the presence of an intraocular tumour. Immunoscintigraphic studies using technetium-labelled antimelanoma antibodies initially and 9 months later yielded positive results with the increasing antibody titer.

[The surgical treatment of strabismus and diplopia in Graves-Basedow ophthalmopathy].

Purpose: The aim of the study is to evaluate results of surgical treatment of strabismus and diplopia in Graves-Basedow ophthalmopathy.

Material And Methods: The surgical procedure was performed in 40 patients with horizontal strabismus, horizontal strabismus with vertical deviation or isolated vertical strabismus. There were performed 86 surgical procedures on the eye muscles (in 20 cases adjustable sutures were used).

[New technique for implanting Bomirski melanoma into the anterior chamber of Syrian hamster eyes].

Purpose: To describe a newly elaborated ocular tumor model, obtained by implanting Bomirski melanoma into the anterior chamber of the eye in Syrian hamsters (Mesocricetus auratus).

Material And Methods: The experiments were carried out using pigmented and non-pigmented lines of the tumor. Attempted injections of suspension of malignant melanoma cells in physiological salt solution to the anterior chamber with an infusion pump did not give the expected results.

[The efficacy of "Ticlid" in treatment of diabetic retinopathy].

Purpose: The efficacy of "Ticlid" (ticlopidine) with insulin-dependent patients and early forms of diabetic retinopathy was evaluated.

Material And Methods: Examinations were carried out with 52 patients (103 eyes), including 31 women and 21 men, average age--39.9.

[Preliminary results of laser coagulation of the retina in the treatment of diabetic retinopathy in pregnant women].

The authors observed a group of 16 pregnant women aged 22-38 years with insulin-dependent diabetes of D, R, RF class (accor. to White). All the patients were treated by conventional insulin therapy.

[Evaluation of the effectiveness of prostacyclin in the treatment of thrombosis of the central retinal vein using a double-blind method].

The patients were divided by chance into 2 groups: the first one (15 persons) was given a natrium salt of prostacyclin (Epoprostenol Wellcome or Chinoin) in a dose of 5 mg/kg/min. intravenously by an infusion pump in 5 infusions; the control group (15 persons) received instead of prostacyclin a placebo (0.1 M glycine buffer of pH 10.

Diabetic retinopathy and previous insulin therapy as compared with insulin requirement.

The aim of study was the comparison of the Biostator-determined insulin requirement with the degree of diabetic retinopathy and previous insulin therapy. Twenty-three patients with insulin-dependent diabetes mellitus of more than 10 years' duration were studied. The mean insulin dosage during the last ten years was calculated, and the degree of retinopathy and insulin requirement during a 2-day connection to the Biostator were determined.