Outcome prediction of initial lamotrigine monotherapy in adult patients with newly diagnosed localization related epilepsies.

Objective: To develop and test model to predict outcome of treatment with initial lamotrigine monotherapy in adult patients with newly diagnosed localization - related epilepsy, using data available at the time of diagnosis.

Methods: Prospective longitudinal study included consecutive series of adult patients with newly diagnosed localization - related epilepsy started of lamotrigine monotherapy. Logistic regression analysis using backward procedure was performed with treatment failure as the outcome variable.

Idiopathic intracranial hypertension from the perspective of headache center.

Idiopathic intracranial hypertension (IIH) is a pathological state defined as an increase of intracranial pressure in the absence of a causative pathological process. The aim of this study was to evaluate the clinical features of the patients with IIH diagnosed in our Headache Center according to the current knowledge of this disorder. In the retrospective and cross-sectional analysis of 3395 patients we present 12 newly diagnosed IIH patients, ten women and two men, aged from 19 to 51, with obtained values of cerebrospinal fluid pressure between 250 and 680 mm of water.

Artificial neural networks based early clinical prediction of mortality after spontaneous intracerebral hemorrhage.

Numerous outcome prediction models have been developed for mortality and functional outcome after spontaneous intracerebral haemorrhage (ICH). However, no outcome prediction model for ICH has considered the impact of care restriction. To develop and compare results of the artificial neural networks (ANN) and logistic regression (LR) models, based on initial clinical parameters, for prediction of mortality after spontaneous ICH.

[Syringomyelia in demyelinating disease of the central nervous system: report of two cases].

Introduction: Syringomyelia is a cavitary extension inside the spinal cord which can be either symptomatic or congenitally-idiopathic. Syringomyelia during the course of the disease in patients presenting with clinically definite multiple sclerosis was described earlier. Syringomyelia in patients presenting with a clinically isolated syndrome suggestive of multiple sclerosis is unusual.

[Epileptic seizure as the first sign of hypoparathyroidism].

Background: Hypoparathyroidism refers to a group of disorders in which extracellular calcium levels cannot be maintained within the normal range due to relative or absolute deficiency of parathyroid hormone (PTH). The clinical features of hypoparathyroidism are consistent with hypocalcaemia and, predominantly, neuromuscular dysfunction. Although hypocalcaemia-induced seizures are well documented hypoparathyroidism-induced epilepsy is often misdiagnosed as idiopathic epilepsy.

A case of complex arteriovenous malformation with skull destruction presented in sixth decade of life.

Intracranial AVMs are typically diagnosed before the patient has reached the age of 40 years, and a few cases have been reported of AVM with skull destruction. We described a rare case of a complex cerebral AVM with skull destruction, presented de novo in 52-year-old woman with epileptic seizures. Neuroimaging investigations revealed complex AVM in right hemisphere as well as extracranially, with signs of skull destructions, likely caused by significant involvement of feeders from external carotid artery.

[Gender difference in hipolipemic and anti-inflammatory effects of statins in diabetics with coronary artery disease].

Background/aim: Statins produce hipolipemic and pleotropic effects on markers of inflammation with stabilization of atheromatous plaque. The aim of this paper was to examine gender difference in hipolipemic and antiinflammatory effects of statins in patients with diabetes mellitus (DM) type 2 with coronary artery disease (CAD).

Methods: Sixty dyslipidemic patients with DM type 2 were analyzed.

Epileptic seizures due to multiple cerebral cavernomatosis.

Background: Cavernous angiomas are angiographically occult vascular malformations that are present in 0.4-0.9% of people, and represent around 5% of all cerebrovascular malformations.

[Cessation of epileptic seizures series using peroral valproate in an adult patient with partial epilepsy].

Introduction: Golden rule for the initiation of antiepileptic therapy in the majority of epileptic syndromes is "start low and go slow", a principle after the second unprovoked seizure. There are certain clinical situations however when fast titration of antiepileptic medication is needed.

Case Report: We present a case of the 48-year-old man referred for further management of uncontrolled partial seizures.

Peripheral nerve conduction study in workers exposed to a mixture of organic solvents in paint and lacquer industry.

Aim: To compare levels of combined exposure to white spirit, toluene, butyl acetate, ethyl acetate, and xylene in the manufacturing of paint, cartridge, drying, and top-coat sections of paint and lacquer industry, and peripheral nerve conduction parameters in the exposed workers.

Methods: The exposed group comprised 120 workers while the control group included 110 workers who had never been exposed to the above listed organic solvents. Nerve conduction studies of the radial and tibial anterior nerve were performed in both groups.