J Clin Endocrinol Metab
May 2017
Context: Low bone density is a complication of cystic fibrosis (CF).
Hypothesis: Accrual of bone mass is most impaired in the sickest children, as judged by nutritional status and pulmonary function.
Design: Retrospective analysis of correlation between lumbar spine bone mineral density (BMD), body mass index (BMI), and forced expiratory volume in 1 second (FEV1) z scores in children and adolescents with CF.
Background: Several cases of Burkholderia pseudomallei infection in CF have been previously reported. We aimed to identify all cases globally, risk factors for acquisition, clinical consequences, and optimal treatment strategies.
Methods: We performed a literature search to identify all published cases of B.
A 12 ½ year old male with cystic fibrosis presented with growth failure after itraconazole was added to a treatment regimen including inhaled and intranasal glucocorticoids. Investigations showed severe adrenal suppression. This case demonstrates the potential for exogenous glucocorticoids to accumulate when their degradation is inhibited by a CYP3A4 inhibitor.
View Article and Find Full Text PDF