Publications by authors named "Mirjam Wagner"
Connections between the nucleus and the cytoskeleton are important for positioning and division of the nucleus. In most eukaryotes, the linker of nucleoskeleton and cytoskeleton (LINC) complex spans the outer and inner nuclear membranes and connects the nucleus to the cytoskeleton. In opisthokonts, it is composed of Klarsicht, ANC-1 and Syne homology (KASH) domain proteins and Sad1 and UNC-84 (SUN) domain proteins.
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- The mitochondrial AAA ATPase Msp1 is crucial for extracting mislocalized proteins from the mitochondrial outer membrane and interacts genetically with the proteasome and TOM complex.
- Msp1 and the proteasome work together to eliminate precursor proteins that get stuck during import, with proteasome activity being vital for this process.
- The study also highlights the potential link between Msp1's function and neurodegenerative diseases in humans, showing that its absence can trigger stress responses in other organisms, suggesting a conserved biological role.