Publications by authors named "Mirjam Geibel"
A defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures. In Alzheimer's disease, this is characterized by the deposition of β-amyloid and tau with disease-specific conformations. The in situ structure of amyloid in the human brain is unknown.
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- The study investigates how various environmental factors, such as temperature and nutrition, influence the different larval stages of Caenorhabditis elegans postembryonic development.
- Results indicate that each larval stage reacts uniquely to these factors, suggesting that developmental timing is finely tuned by stage-specific events.
- Understanding these mechanisms may enhance our knowledge of how developmental timing is regulated in organisms.
Brain and muscle ARNT-like protein-1 (BMAL-1) is an important component of the cellular circadian clock. Proteins such as epidermal (EGF) or nerve growth factor (NGF) affect the cellular clock via extracellular signal-regulated kinases-1/2 (ERK-1/2) in NIH3T3 or neuronal stem cells, but no such data are available for the insulin-like growth factor-1 (IGF-1). The hypothalamus expresses receptors for all three growth factors, acts as a central circadian pacemaker, and releases hormones in a circadian fashion.
View Article and Find Full Text PDFCaenorhabditis elegans postembryonic development consists of four discrete larval stages separated by molts. Typically, the speed of progression through these larval stages is investigated by visual inspection of the molting process. Here, we describe an automated method to monitor the timing of these discrete phases of C.
View Article and Find Full Text PDFDysregulation of hypothalamic-pituitary-adrenal (HPA) axis activity leads to debilitating neuroendocrine or metabolic disorders such as Cushing's syndrome (CS). Glucocorticoids control HPA axis activity through negative feedback to the pituitary gland and the central nervous system (CNS). However, the cellular mechanisms involved are poorly understood, particularly in the CNS.
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- The study investigates the role of brain-derived neurotrophic factor (Bdnf) signaling in enkephalinergic striatopallidal neurons, particularly in the context of Huntington's disease.
- It highlights how changes in Bdnf levels and its transport can make these neurons more vulnerable and affect their functions.
- The findings show that disrupting Bdnf-TrkB signaling leads to increased movement, suggesting this pathway plays a crucial role in regulating locomotion by affecting the activity of specific neurons in response to signals.
Article Synopsis
- Many molecules in the central nervous system (CNS) play roles in cognitive functions by influencing neuron activity and support.
- The study investigated the role of nerve growth factor (NGF) and its receptor TrkA in behaviors related to attention and memory, particularly in key brain regions like the hippocampus and amygdala.
- The research found that while NGF-TrkA signaling is not crucial for the survival of most cholinergic neurons or for key cognitive functions, it is not necessary for attention and learning capabilities in mice.