Publications by authors named "Mirinthorn Jutanom"
Article Synopsis
- - Recent research highlights mitochondrial dysfunction as a key factor in the development and progression of age-related macular degeneration (AMD), affecting crucial metabolic processes like oxidative phosphorylation and glycolysis.
- - The study investigates oxidized low-density lipoprotein (ox-LDL), found in drusen, and its impact on metabolic changes in retinal pigment epithelial (RPE) cells, revealing that prolonged exposure leads to altered fatty acid β-oxidation, OXPHOS, and increased reactive oxygen species production.
- - The research also critiques conventional ARPE-19 cell lines used in AMD studies, noting their limitations compared to stem cell-derived RPE cells, which could provide better insights into the disease mechanisms.
Article Synopsis
- Milk is highly nutritious, but lipid oxidation is a key factor in its spoilage, requiring effective prevention measures.
- The study investigated oxidation mechanisms in long-life milk and analyzed specific lipid oxidation products using advanced techniques.
- Findings indicate that long-life milk is more prone to photo-oxidation than thermal oxidation, emphasizing the role of radicals and suggesting strategies to prevent oxidation in milk and related products.
Glucosylceramide (GlcCer) belongs to sphingolipids and is found naturally in plant foods and other sources that humans consume daily. Our previous studies demonstrated that GlcCer prevents inflammatory bowel disease both in vitro and in vivo, whose patients are increasing alarmingly. Although some lipids are vulnerable to oxidation which changes their structure and activities, it is unknown whether oxidative modification of GlcCer affects its activity.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the differences in cellular uptake of Vitamin E forms, tocopherol (Toc) and tocotrienol (T3), focusing on the role of serum albumin as a contributing factor.
- - Adding bovine serum albumin (BSA) in serum-depleted media increased T3 uptake while decreasing Toc uptake, showing varying effects among different analogs of both forms.
- - The research indicates that T3 binds to albumin with a higher affinity than Toc, due to variations in side chains, which influences their cellular uptake mechanisms, offering insights into Vitamin E's physiological roles.
Article Synopsis
- This study investigates the potential of 4β-Hydroxycholesterol (4β-HC) as a biomarker for assessing the induction of the CYP3A4 enzyme during drug development.
- The researchers optimized protocols for plasma collection and storage, discovering that inappropriate storage leads to the formation of a cholesterol oxidation product, which can signal when samples are compromised.
- By effectively measuring 4β-HC levels in their clinical trials with novel drug candidates, they demonstrated that weak CYP3A4 inducers could be detected without needing a probe substrate, enhancing the reliability of drug interaction studies.
Article Synopsis
- - The study focuses on a specific glycolipid from oats, known as digalactosyldiacylglycerol-monoestolide (DGDG-monoestolide), which has a unique structure where a fatty acid is replaced by a hydroxy fatty acid ester.
- - DGDG-monoestolide identified in oats, specifically DGDG-LAHLA, was shown to reduce the production of inflammatory markers in cell experiments, highlighting its potential anti-inflammatory properties.
- - The research suggests that both intact DGDG-LAHLA and its metabolites might play a role in its anti-inflammatory effects, potentially promoting the health benefits of oats as a functional food.
Previously, we reported that the polar lipid fraction from the golden oyster mushroom, Pleurotus citrinopileatus, suppresses colon injuries which result from apoptosis induced by inflammatory stresses in vivo and in vitro (Yamashita et al., J. Oleo Sci.
View Article and Find Full Text PDFThe rising incidence of inflammatory bowel disease (IBD) in East Asian countries has necessitated the implementation of preventive methods in the form of dietary supplementation and changes in dietary habits. We have previously reported that dietary golden oyster mushroom (Pleurotus citrinopileatus) ethanol extract (GOMEE) suppresses intestinal inflammation in mouse models of IBD induced by dextran sulfate sodium salt (DSS). Here, we investigated the components of GOMEE that exert suppressive effects on colon inflammation in vivo and in vitro.
View Article and Find Full Text PDF