Publications by authors named "Mirian Krystel De Siqueira"
Adipose tissue regulates energy homeostasis and metabolic function, but its adaptability is impaired in obesity. In this study, we investigate the impact of acute PPARγ agonist treatment in obese mice and find significant transcriptional remodeling of cells in the stromal vascular fraction (SVF). Using single-cell RNA sequencing, we profile the SVF of inguinal and epididymal adipose tissue of obese mice following rosiglitazone treatment and find an induction of ribosomal factors in both progenitor and preadipocyte populations, while expression of ribosomal factors is reduced with obesity.
View Article and Find Full Text PDFMicrobiota configuration determines nutritional immune optimization.
Proc Natl Acad Sci U S A
December 2023
Article Synopsis
- - Mild dietary restriction (DR) improves health and immune responses, specifically by optimizing memory T cells and their interactions with myeloid cells in fighting infections.
- - DR promotes the growth of beneficial gut bacteria like Bifidobacteria, which produce acetate that enhances myeloid cell function against pathogens.
- - The effectiveness of DR on immunity relies on a healthy gut microbiota, illustrating how nutrition influences immune cooperation and response to infections.
The microbiota performs multiple functions vital to host fitness, including defense against pathogens and adaptation to dietary changes. Yet, how environmental challenges shape microbiota resilience to nutrient fluctuation remains largely unexplored. Here, we show that transient gut infection can optimize host metabolism toward the usage of carbohydrates.
View Article and Find Full Text PDFArticle Synopsis
- * This tissue can dramatically change its metabolism, structure, and characteristics in response to physiological needs, showcasing its high plasticity.
- * When this plasticity is impaired, it can lead to poor responses to bodily signals, contributing to cardiometabolic diseases and other health issues linked to obesity.
Article Synopsis
- A study by Zhang et al. (2021) finds that lowering iron levels in fat tissue can enhance metabolic function.
- This improvement happens via a communication process between organs, where signals from fat cells decrease the absorption of fats in the intestines.
- The research highlights the potential link between iron levels and metabolism, suggesting new avenues for weight management and metabolic health.
Changing the immune responses to allergens is the cornerstone of allergen immunotherapy. Allergen-specific immunotherapy that consists of repeated administration of increasing doses of allergen extract is potentially curative. The major inconveniences of allergen-specific immunotherapy include failure to modify immune responses, long-term treatment leading to non-compliance and the potential for developing life-threating anaphylaxis.
View Article and Find Full Text PDFBackground: A new isolate of Aura virus serendipitously discovered as a cell culture contaminant is reported in this manuscript. Aura virus belongs to the family Togaviridae and is classified in the genus Alphavirus. There are only two reports of Aura virus isolation from mosquitoes in the scientific literature, and the existence of a vertebrate host is still unknown.
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