Publications by authors named "Miriam Wronski"
Background: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common complication of chimeric antigen receptor (CAR) T-cell therapy. Current practice guidelines recommend the immune effector cell-associated encephalopathy (ICE) score for the assessment and monitoring of ICANS.
Objective: To demonstrate modifications to ICE score to patients with vision and hearing impairments or who are who are from non-native-speaking backgrounds.
Article Synopsis
- The study investigates the impact of the COVID-19 pandemic on rapid outpatient TIA (transient ischemic attack) clinics, aiming to understand effects on TIA incidence and hospital services.
- Data from six medical centers over three years (pre- and intra-COVID) were analyzed for TIA and ischemic stroke presentations, as well as treatments like IV thrombolysis and endovascular thrombectomy.
- Results showed stable TIA clinic activity during the pandemic, but a decrease in the proportion of ischemic strokes treated with IV thrombolysis, indicating potential delays in patients seeking urgent treatment that need addressing in public health strategies.
Article Synopsis
- Cerebral venous thrombosis (CVT) associated with vaccine-induced immune thrombotic thrombocytopenia (VITT) has high in-hospital mortality, but outcomes are better for those who survive hospitalization after SARS-CoV-2 vaccination.
- In a study of 107 CVT-VITT cases, 40% died during initial hospitalization, but of the 60 patients who survived, 88% achieved functional independence after a median follow-up of 150 days.
- No new thrombotic events were reported post-discharge, and only one case of major bleeding occurred, indicating a generally positive prognosis for survivors.
Article Synopsis
- The study investigates the treatment of cerebral venous thrombosis (CVT) caused by vaccine-induced immune thrombotic thrombocytopenia (VITT) following adenovirus-based COVID-19 vaccinations.
- Researchers analyzed data from 99 patients across 17 countries to assess adherence to recommended treatments, including immunomodulation and avoiding certain anticoagulants.
- While overall adherence to these treatment guidelines did not significantly impact mortality, patients who received immunomodulation showed lower mortality rates compared to those who did not.