Publications by authors named "Miriam Watafua"
Article Synopsis
- Butyrylcholinesterase (BChE) plays a crucial role in the progression of Alzheimer's disease, as its normal function is disrupted in patients with advanced AD, impacting cholinergic neurotransmission.
- Research utilized enzyme kinetic studies, molecular modeling, and protein-ligand interactions to investigate how methylrosmarinate interacts with BChE, revealing that it binds effectively in BChE's active site and stabilizes interactions with various subsites.
- The study found that methylrosmarinate significantly inhibits BChE, with specific kinetic values indicating it could be a promising inhibitor, although the exact mechanisms of this inhibition in relation to various disease conditions need further research.
The plant (Fabaceae) is traditionally used to manage hepatitis. This research work aims to investigate the hepatoprotective effectiveness of root bark extract of (ASE) against paracetamol (PCM) and bile duct ligation (BDL)-induced hepatotoxicity. The phytochemical and median lethal dose (LD) investigations were conducted.
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