Publications by authors named "Miriam Viesti"
Article Synopsis
- Interleukin (IL)-1α is linked to atherosclerosis, prompting research on a vaccine that neutralizes it.
- ApoE-deficient mice were immunized with a specially designed vaccine containing IL-1α to observe its effects on atherosclerosis progression.
- The results showed a significant reduction in plaque growth and inflammation, suggesting that targeting IL-1α could be a promising approach for treating atherosclerosis.
Extracellular proteolysis plays an essential role in synaptic remodeling that is indispensable for cognitive function. The extracellular serine protease neurotrypsin was implicated in cognitive function, because humans lacking a functional form of neurotrypsin suffer from severe mental retardation. By immunoelectron microscopy, neurotrypsin has been localized to presynaptic terminals, suggesting a local proteolytic function after its synaptic release.
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