Publications by authors named "Miriam Vanunu"
, which causes tuberculosis disease, continues to be a major global health threat. Correct identification of valid drug targets is important for the development of novel therapeutics that would shorten the current 6-9 month treatment regimen and target resistant bacteria. Methionine aminopeptidases (MetAP), which remove the N-terminal methionine from newly synthesized proteins, are essential in all life forms (eukaryotes and prokaryotes).
View Article and Find Full Text PDFMycobacterium tuberculosis is a major health threat, necessitating novel drug targets. Protein synthesis in bacteria uses initiator tRNA charged with formylated methionine residue. Deletion of the formylase gene, tRNA-formyl transferase (fmt), causes severe growth-retardation in E.
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- Phenotypic plasticity in plants allows them to adapt to environmental stresses by perceiving and responding to cues from nearby damaged plants.
- The study tested how unstressed plants react to stress signals from drought- and osmotic-stressed neighbors through experiments with split-root systems.
- Results showed that while stressed plants closed their stomata in response to stress, unstressed neighbors adapted by eventually reopening their stomata, highlighting a new form of plant communication that could prepare them for future stresses.