Publications by authors named "Miriam Mangiarelli"
J Cancer Res Clin Oncol
February 2021
Article Synopsis
- Many studies suggest that contralateral breast cancer (CBC) might actually be metastatic spread from the primary tumor rather than a new independent cancer, making understanding their clonal relationship important for treatment and prognosis.
- Mitochondrial DNA (mtDNA) sequencing is highlighted as a useful tool for determining if CBCs share a common origin, showing its potential to improve diagnostic accuracy beyond standard pathology methods.
- In a study involving 30 sample pairs, mtDNA analysis identified a clonal relationship in 23% of cases, including clarifying ambiguous diagnoses that traditional methods could not resolve, indicating mtDNA sequencing could enhance routine cancer diagnosis.
