Publications by authors named "Miriam Maccarrone"
Article Synopsis
- The study aimed to evaluate the risks of recurrent ischemic events and severe bleeding in patients with acute posterior ischemic stroke (PS) and atrial fibrillation (AF) in relation to oral anticoagulant therapy (OAT) and timing of initiation.
- Researchers compared outcomes in 473 patients with PS to 1997 patients with anterior stroke (AS), focusing on events within 90 days of the initial stroke.
- Findings indicated that both PS and AS patients had similar risks of ischemic or hemorrhagic events at 90 days, regardless of when OAT was initiated.
Article Synopsis
- - This study investigates ischemic cerebrovascular events in patients with nonvalvular atrial fibrillation (AF) who are being treated with non-vitamin K antagonist oral anticoagulants (NOACs) to identify risk factors and understand the underlying mechanisms.
- - The research involved 713 patients who experienced ischemic strokes or transient ischemic attacks while on NOACs, and 700 who did not, revealing significant associations between these events and factors like low NOAC dosage, atrial enlargement, hyperlipidemia, and higher CHADS-VASc scores, which indicate greater stroke risk.
- - Findings suggest that while most strokes in this population were of cardioembolic origin, other factors such as being older,
The pathophysiological mechanisms of cognitive and gait disturbances in subjects with normal-pressure hydrocephalus (NPH) are still unclear. Cholinergic and other neurotransmitter abnormalities have been reported in animal models of NPH. The objective of this study was to evaluate the short latency afferent inhibition (SAI), a transcranial magnetic stimulation protocol which gives the possibility to test an inhibitory cholinergic circuit in the human brain, in subjects with idiopathic NPH (iNPH).
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- * Researchers analyzed data from 1,810 patients, discovering that 20% underwent this bridging therapy, and found that bridged patients had worse outcomes, with a higher rate of ischemic events and major bleeding.
- * The results indicate that bridging therapy significantly raises the risk of early complications compared to patients who did not receive it, prompting a reevaluation of its common use in clinical practice.
Article Synopsis
- The study examined the link between types of atrial fibrillation (paroxysmal vs. sustained) and the occurrence of early ischaemic recurrences after an acute stroke in patients.
- Out of 2150 patients, those with sustained atrial fibrillation experienced a higher percentage of early ischaemic recurrences (6.2%) compared to those with paroxysmal atrial fibrillation (3.3%).
- However, after considering other health risks, sustained atrial fibrillation did not show a significantly increased risk for early recurrence, suggesting that other factors may be more influential.
Background In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents ischemic recurrence but with the risk of hemorrhagic transformation ( HT ). The aims of this study were to evaluate in consecutive patients with acute stroke and atrial fibrillation (1) the incidence of early HT, (2) the time to initiation of anticoagulation in patients with HT , (3) the association of HT with ischemic recurrences, and (4) the association of HT with clinical outcome at 90 days. Methods and Results HT was diagnosed by a second brain computed tomographic scan performed 24 to 72 hours after stroke onset.
View Article and Find Full Text PDFEarly Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non-Vitamin-K Oral Anticoagulants (RAF-NOACs) Study.
J Am Heart Assoc
November 2017
Article Synopsis
- The study investigates the optimal timing for administering non-vitamin K oral anticoagulants (NOACs) in patients with acute ischemic stroke and atrial fibrillation, focusing on early recurrence of stroke and major bleeding within 90 days post-treatment.
- A total of 1,127 patients participated, with diverse treatment groups receiving dabigatran, rivaroxaban, or apixaban; results revealed a low incidence of early recurrence (2.8%) and major bleeding (2.4%).
- Patients starting NOACs within 2 days of stroke had higher rates of complications (12.4% composite rate), compared to delayed initiation (3-14 days had 2.1%, and >14 days
Background And Purposes: This study was designed to derive and validate a score to predict early ischemic events and major bleedings after an acute ischemic stroke in patients with atrial fibrillation.
Methods: The derivation cohort consisted of 854 patients with acute ischemic stroke and atrial fibrillation included in prospective series between January 2012 and March 2014. Older age (hazard ratio 1.