Acetylsalicylic Acid Treatment in Patients With Sepsis and Septic Shock: A Phase 2, Placebo-Controlled, Randomized Clinical Trial.

Objectives: Platelets play a critical role in the inflammatory response and coagulation. We aimed to evaluate whether the use of acetylsalicylic acid (ASA) would reduce the intensity of organ dysfunction in septic patients.

Design: Randomized, blinded, parallel-group, placebo-controlled trial.

Comparison of lactate values obtained from different sites and their clinical significance in patients with severe sepsis.

Context And Objective: The ideal site for lactate collection has not been clearly established. This study aimed to evaluate associations between lactate levels in arterial blood (Lart), peripheral venous blood (Lper) and central venous blood (Lcen) in patients with severe sepsis or septic shock.

Design And Setting: Cross-sectional analytical study in an tertiary university hospital.

Central and mixed venous oxygen saturation in septic shock: is there a clinically relevant difference?

Introduction: Central venous oxygen saturation (SvcO2) has been proposed as an alternative for mixed venous oxygen saturation (SvO2), with a variable level of acceptance according to available data. This study aimed to evaluate possible differences between SvO2 and SvcO2 or atrial venous saturation (SvaO2), with emphasis on the role of cardiac output and their impact on clinical management of the septic patient.

Methods: This is an observational, prospective study of patients with septic shock monitored by pulmonary artery catheter.