Long-Term Outcomes of 5-Fluorouracil-Related Early-Onset Toxicities: A Retrospective Cohort Study.

Objectives: We aimed to determine whether the occurrence of early-onset toxicities due to 5-fluorouracil (5-FU) in treatment-naive patients undergoing their first cycle of FOLFOX/FOLFIRINOX was associated with decreased overall survival, increased risk of treatment cessation, and hospitalization.

Methods: This was a retrospective cohort study using patient information from community oncology practices. Patients who received their first dose of 5-FU from 1 January 2015 through 1 August 2023 were included.

Bladder and bowel function effects on emotional functioning in youth with spinal cord injury: a serial multiple mediator analysis.

Study Design: Preliminary explanatory or mechanistic cross-sectional study.

Objectives: This preliminary cross-sectional study investigates the hypothesized serial mediating effects of bladder/bowel worry, social worry, and social participation in the relationship between bladder function or bowel function and emotional functioning in youth with spinal cord injury (SCI) from their perspective.

Methods: The Bladder Function, Bowel Function, Worry Bladder Bowel, Worry Social, and Social Participation Scales from the PedsQL™ Spinal Cord Injury Module and the Emotional Functioning Scale from the PedsQL™ 4.

A Systematic Review of High-Dose Methotrexate for Adults with Primary Central Nervous System Lymphoma.

Primary central nervous system lymphoma (PCNSL) is a highly aggressive non-Hodgkin lymphoma that is confined within the CNS. Due to its ability to cross the blood-brain barrier, high-dose methotrexate (HDMTX) is the backbone for induction chemotherapy. This systematic review was conducted to observe outcomes among different HDMTX doses (low, <3 g/m; intermediate, 3-4.

Pain, pain interference, social and school/work functioning in youth with spinal cord injury: A mediation analysis.

Context/objective: The objective of the present study was to investigate the effects of pain severity, pain interference and social functioning in a serial multiple mediator model predicting school/work functioning in youth with spinal cord injury (SCI) from their perspective.

Design: Explanatory or mechanistic study.

Setting: Pediatric specialty hospital.

PedsQL™ Spinal Cord Injury Module: Reliability and Validity.

Objectives: The objective was to report on the initial measurement properties of the Pediatric Quality of Life Inventory™ (PedsQL™) Spinal Cord Injury (SCI) Module in youth with SCI from the youth and parent perspectives.

Methods: PedsQL™ SCI Module and PedsQL™ 4.0 Generic Core Scales SF15 were completed in a multisite national study by 166 youth ages 8 to 25 years and 128 parents of youth ages 5 to 23 years.

Gait Characteristics in Youth With Transverse Myelitis.

Background: Transverse myelitis (TM) in childhood is a rare disorder characterized by the presence of spinal cord inflammation. Gait difficulty in children with TM is common; however, there is a paucity of literature regarding quantitative assessment of gait in children and adolescents with TM.

Objectives: To characterize gait patterns in a cohort of ambulatory children with TM and age-matched, typically developing peers in order to better understand the functional mobility of patients diagnosed with childhood TM.

Development of the Pediatric Quality of Life Inventory™ Spinal Cord Injury (PedsQL™ SCI) module: qualitative methods.

Study Design: It is a qualitative study.

Objectives: To develop the items and support content validity for the Pediatric Quality of Life Inventory™ (PedsQL™) Spinal Cord Injury Module for youth and emerging adults with spinal cord injury (SCI).

Setting: Community and children's hospital.

The International Spinal Cord Injury Pediatric Activity and Participation Basic Data Set.

Study Design: International focus groups.

Objectives: The objective of this project was to develop the International Spinal Cord Injury (SCI) Pediatric Activity and Participation (A&P) Basic Data Set.

Methods: A focus group of experts in pediatric and adult SCI, and contributors of the existing adult International SCI Adult A&P Basic Data Set convened to develop an initial draft of the data set, which was iteratively refined over a 12 month period based on relevant literature and existing outcome measures that evaluate pediatric activity and participation.

Development of the International Spinal Cord Injury/Dysfunction Education Basic Data Set.

Study Design: Consensus among international experts.

Objectives: The objective of this project was to develop the International Spinal Cord Injury/Dysfunction (SCI/D) Education Basic Data Set.

Setting: International expert working group.

Long-Term Outcomes and Longitudinal Changes of Neurogenic Bowel Management in Adults With Pediatric-Onset Spinal Cord Injury.

Objectives: To describe long-term outcomes of neurogenic bowel dysfunction (NBD), determine changes over time in the type of bowel program, and determine changes in psychosocial outcomes associated with NBD-related factors in adults with pediatric-onset spinal cord injury (SCI).

Design: Longitudinal cohort survey. Follow-up occurred annually for a total of 466 interviews, with most participants (75%) contributing to at least 3 consecutive interviews.

Occupational characteristics of adults with pediatric-onset spinal cord injury.

Background: Employment rates among individuals with spinal cord injury (SCI) are lower than in the general population and little is known about the specific occupations in which they are employed.

Objectives: To describe specific occupations of adults with pediatric-onset SCI using the 2010 Standard Occupational Classification (SOC) system and to determine associations between SOC occupations and demographic factors.

Methods: Cross-sectional data specific to education and employment were collected from the last interviews of a larger longitudinal study.

Longitudinal changes in medical complications in adults with pediatric-onset spinal cord injury.

Objectives: To determine longitudinal changes in the occurrence of medical complications in adults with pediatric-onset spinal cord injury (SCI).

Design: Longitudinal study of long-term outcomes.

Setting: Community.

Normative blood pressure and heart rate in pediatric spinal cord injury.

Background: Cardiovascular measures in children with spinal cord injury (SCI) may vary depending on the child's age and physical development in addition to injury-related factors. Developmental changes should be considered when addressing cardiovascular complications in this population.

Objectives: To determine baseline blood pressure (BP) and heart rate (HR) measurements in youth with SCI, and to investigate differences in BP and HR in relation to age, gender, body mass index (BMI), and injury-related factors.

Autonomic cardiovascular dysfunction and vitamin D deficiency in pediatric spinal cord injury.

Objective: The purpose of this manuscript is to present a general overview and preliminary results of pilot projects of two complications in pediatric spinal cord injury (SCI): autonomic cardiovascular dysfunction and vitamin D deficiency.

Methods: Retrospective cross-sectional investigations of blood pressures (BP), heart rates (HR), and vitamin D levels were performed.

Results: Among 279 children with SCI, it was observed that baseline BP increases and HR decreases with increasing age.

Measuring care and comfort in children with cerebral palsy: the care and comfort caregiver questionnaire.

Objective: To evaluate the psychometric properties of the Care and Comfort Caregiver Questionnaire (CareQ), which was developed to measure the perceived effort of caregivers in providing care for children with moderate to severe cerebral palsy (CP).

Design: Cross-sectional data collection from a representative sample of a large racially/ethnically diverse geographic region.

Setting: Outpatient CP clinics at a metropolitan rehabilitation institution.

Changes of calf muscle-tendon biomechanical properties induced by passive-stretching and active-movement training in children with cerebral palsy.

Biomechanical properties of calf muscles and Achilles tendon may be altered considerably in children with cerebral palsy (CP), contributing to childhood disability. It is unclear how muscle fascicles and tendon respond to rehabilitation and contribute to improvement of ankle-joint properties. Biomechanical properties of the calf muscle fascicles of both gastrocnemius medialis (GM) and soleus (SOL), including the fascicle length and pennation angle in seven children with CP, were evaluated using ultrasonography combined with biomechanical measurements before and after a 6-wk treatment of passive-stretching and active-movement training.

Combined passive stretching and active movement rehabilitation of lower-limb impairments in children with cerebral palsy using a portable robot.

Background: Ankle impairments are closely associated with functional limitations in children with cerebral palsy (CP). Passive stretching is often used to increase the range of motion (ROM) of the impaired ankle. Improving motor control is also a focus of physical therapy.

Efficacy of robotic rehabilitation of ankle impairments in children with cerebral palsy.

The current study introduces a novel rehabilitation robot for treatment of impaired ankle in children with cerebral palsy (CP). The treatment consisted of passive stretching under intelligent control and active movement training with motivating game-playing using the portable robot. After 18 sessions of training (3 sessions/week for 6 weeks), we found significant improvement in 12 children with CP in terms of improved passive and active ranges of motion, selective motor control and mobility functions.

Medial and lateral branches of the superficial radial nerve: cadaver and nerve conduction studies.

Objective: To establish a reliable technique for nerve conduction study (NCS) of medial and lateral branches of the superficial radial nerve (SRN).

Methods: The distribution of SRN and its branches were examined in 10 cadavers. Based on the cadaveric study, anti-dromic nerve conduction studies were performed on 31 healthy subjects.

Amplitude ratio of ulnar sensory nerve action potentials in segmental conduction study: reference values in healthy subjects and diagnostic usefulness in patients with ulnar neuropathy at the elbow.

Objective: To determine normal values for the amplitude ratio of sensory nerve action potential (SNAP) from an ulnar sensory segmental nerve conduction study, and to the evaluate usefulness in the diagnosis of mild-degree ulnar neuropathy at the elbow (UNE).

Design: Segmental sensory conduction study of the ulnar nerve was performed in 71 healthy subjects. Peak latency and baseline to peak amplitudes were measured.

Intramuscular hemangioma mimicking myofascial pain syndrome: a case report.

Intramuscular hemangioma, an infrequent but important cause of musculoskeletal pain, is often difficult to establish the diagnosis clinically. This report describes a case of a 32-yr-old woman who presented with severe left calf pain for 10 yr. Initial conservative treatments consisting of intramuscular electrical stimulation, herb medication, acupuncture, and intramuscular lidocaine injection under the diagnosis of myofascial pain syndrome in other facilities, failed to alleviate the symptoms.

Meralgia paresthetica caused by hip-huggers in a patient with aberrant course of the lateral femoral cutaneous nerve.

"Hip-huggers" may be a precipitating factor for meralgia paresthetica (MP), especially in thin persons with an aberrant pathway of the lateral femoral cutaneous nerve (LFCN). We describe a 25-year-old woman with a long-standing history of MP caused by an abnormal course of the LFCN and tight trousers, specifically hip-huggers. Ultrasonography was useful for detecting the lesion site and the abnormal pathway of the LFCN.