affects glioblastoma progression by regulating osteopontin-mediated angiogenesis.

Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer with a median survival of only 15 months. To complement standard treatments including surgery, radiation and chemotherapy, it is essential to understand the contribution of the GBM tumor microenvironment. Brain macrophages and microglia particularly contribute to tumor angiogenesis, a major hallmark of GBM.

Fiber tractography of the optic radiations: impact of diffusion model, voxel shape and orientation.

Background: Reliable visualization of the optic radiations (OR) is of major importance in tumor surgery close to the OR to prevent permanent visual field deficits. Diffusion tensor imaging (DTI) based fiber tractography (FT) has become a standard tool to visualize major white matter tracts and to support the prevention of postoperative deficits. Nevertheless, FT of the OR is notoriously challenging due to its high neuroanatomical complexity.