Publications by authors named "Miriam C McDonough"
Article Synopsis
- Excessive production of aldosterone is linked to serious health risks, including heart disease, stroke, dementia, and increased mortality, primarily by promoting sodium retention and consumption.
- Researchers identified specific neurons in the human brain that are sensitive to aldosterone and express a genetic regulator called HSD2, which play a crucial role in salt intake.
- Experimental studies in mice confirmed that these HSD2 neurons are essential for aldosterone-induced salt consumption, suggesting they could be a potential target for treatments aimed at controlling dietary sodium intake.
Control of sodium appetite by hindbrain aldosterone-sensitive neurons.
Mol Cell Endocrinol
October 2024
Mineralocorticoids play a key role in hydromineral balance by regulating sodium retention and potassium wasting. Through favoring sodium, mineralocorticoids can cause hypertension from fluid overload under conditions of hyperaldosteronism, such as aldosterone-secreting tumors. An often-overlooked mechanism by which aldosterone functions to increase sodium is through stimulation of salt appetite.
View Article and Find Full Text PDFNeuropeptide S (NPS) increases wakefulness. A small number of neurons in the brainstem express Nps. These neurons are located in or near the parabrachial nucleus (PB), but we know very little about their ontogeny, connectivity, and function.
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