First Bioprospecting Study of Skin Host-Defense Peptides in .

The adaptation of amphibians to diverse environments is closely related to the characteristics of their skin. The complex glandular system of frog skin plays a pivotal role in enabling these animals to thrive in both aquatic and terrestrial habitats and consists of crucial functions such as respiration and water balance as well as serving as a defensive barrier due to the secretion of bioactive compounds. We herein report the first investigation on the skin secretion of , as a potential source of bioactive peptides and also as an indicator of its evolutionary adaptations to changing environments.