Publications by authors named "Miri Park"

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading global liver disorder. Parsnip (Pastinaca sativa), rich in dietary fiber and medicinal properties, has shown health benefits, but its effects on MASLD are largely unexplored. This study evaluated the prebiotic and anti-MASLD effects of parsnip root water-soluble extract (PRE) in a mouse model.

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(sweet flag), a medicinal plant, especially its rhizome, shows strong antioxidant and anti-inflammatory effects; however, its efficacy in treating intestinal inflammation and obesity is still unexplored. In this study, we investigated the prebiotic activity of sweet flag rhizome extract (SRE) and its preventive effects against high-fat diet (HFD)-induced obesity and colonic inflammation. The prebiotic activity was assessed based on the prebiotic activity scores of four probiotic strains.

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: Dietary patterns, including high-fat and high-carbohydrate diets (HFDs and HCDs), as well as non-dietary factors such as food additives and antibiotics, are strongly linked to metabolic endotoxemia, a critical driver of low-grade chronic inflammation. This review explores the mechanisms through which these factors impair intestinal permeability, disrupt gut microbial balance, and facilitate lipopolysaccharide (LPS) translocation into the bloodstream, contributing to metabolic disorders such as obesity, type 2 diabetes mellitus, and inflammatory bowel disease. : The analysis integrates findings from recent studies on the effects of dietary components and gut microbiota interactions on intestinal barrier function and systemic inflammation.

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Article Synopsis
  • - Excessive sugar intake alters gut microbiota, which is linked to obesity and metabolic issues; this study focused on monosaccharides (glucose and fructose) versus fructooligosaccharides (FOS) effects in germ-free mice.
  • - Mice consuming glucose and fructose showed increased fat accumulation and larger fat cells compared to those fed FOS, which led to healthier metabolic function and significant activation of a key protein involved in metabolism.
  • - FOS not only reduced metabolic problems but also increased goblet cells in the intestinal lining, suggesting beneficial effects that occur independently of the gut microbiota.
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A Gram-strain-negative, aerobic, yellow-colored, non-motile, and rod-shaped bacterial strain, designated IMCC34852, was isolated from a freshwater stream in the Republic of Korea. Cellular growth occurred at 10-37 °C, pH 6.0-9.

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  • - The study analyzed the RSV genome in children during the COVID-19 pandemic in Korea to see if drug-resistant mutations emerged due to the interruption in RSV seasonality.
  • - Researchers collected 288 respiratory samples, conducting whole-genome sequencing on 133, with findings showing no significant changes in RSV strains or resistance to nirsevimab and palivizumab across the pre- and post-pandemic periods.
  • - However, they did identify specific mutations (L172Q and S173L) in all RSV-B samples that confer resistance to suptavumab, indicating a potential issue in treatment effectiveness for some RSV strains.
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Two Gram-stain-negative, aerobic, motile by means of flagella, short rod-shaped bacterial strains, designated IMCC43200 and IMCC45268, were isolated from coastal seawater samples collected from the South Sea of Korea. Strains IMCC43200 and IMCC45268 shared 98.6% 16S rRNA gene sequence similarity and were closely related to Congregibacter litoralis KT71 (98.

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Scope: Long-term consumption of excessive dietary advanced glycation end-products such as N-carboxymethyl-lysine (CML), which are produced by the Maillard reaction during food thermal processing, leads to nonalcoholic fatty liver disease (NAFLD) along with high fat consumption. The study previously finds that administration of Lactococcus lactis KF140 (LL-KF140) detoxifies CML by decreasing CML absorption both in a rat model and clinical trial.

Methods And Results: The present study evaluates the ameliorative effect of LL-KF140 on NAFLD and fatty liver-related biomarkers in a mouse model induced by CML and high fat.

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Ethnopharmacological Relevance: Orostachys japonica (rock pine) has been used as a folk remedy to treat inflammation, hepatitis, and cancer in East Asia.

Aim Of The Study: The aim of this study was to investigate the effect of rock pine extract (RPE) on high-fat diet-induced obesity in mice and to examine its effects on gut dysbiosis.

Materials And Methods: The characteristic compound of RPE, kaempferol-3-O-rutinoside, was quantified using high-performance liquid chromatography.

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Resistant starch serves as a prebiotic in the large intestine, aiding in the maintenance of a healthy intestinal environment and mitigating associated chronic illnesses. This study aimed to investigate the impact of resistant starch-enriched brown rice (RBR) on intestinal health and functionality. We assessed changes in resistant starch concentration, structural alterations, and branch chain length distribution throughout the digestion process using an in vitro model.

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  • A new Gram-stain-negative bacterium, IMCC34845, was discovered in a freshwater stream in South Korea, and is characterized as aerobic, motile, and rod-shaped.
  • Phylogenetic analysis linked it closely to 'Achromobacter panacis,' but genetic testing proved that IMCC34845 and related strains are distinct species.
  • The strain's genetic makeup and chemical properties support its classification as a novel species within its genus, leading to the proposal of a new name for it and recommending a reclassification of 'Achromobacter panacis.'
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The name Flavihumibacter fluminis Park et al. 2022, which was effectively published but invalidated, is an illegitimate homonymic epithet of Flavihumibacter fluminis Guo et al. 2023.

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As a crop quality sensor, Raman spectroscopy has been consistently proposed as one of the most promising and non-destructive methods for qualitative and quantitative analysis of plant substances, because it can measure molecular structures in a short time without requiring pretreatment along with simple usage. The sensitivity of the Raman spectrum to target chemicals depends largely on the wavelength, intensity of the laser power, and exposure time. Especially for plant samples, it is very likely that the peak of the target material is covered by strong fluorescence effects.

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  • Eleven new Flavobacterium bacterial strains were isolated from freshwater and identified through gene sequencing, revealing distinct characteristics and genome sizes.
  • The average nucleotide identity analysis showed that two strains belong to the same species, while the others represent separate novel species, each exhibiting low genetic similarity with known Flavobacterium species.
  • The study proposes ten new species, including Flavobacterium praedii and Flavobacterium marginilacus, based on genomic, phylogenetic, and phenotypic evaluations, confirming their uniqueness from existing species.
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A Gram-stain-negative, aerobic, rod-shaped and motile bacterium, designated IMCC34681, was isolated from a lotus wetland in the Republic of Korea. Cellular growth occurred at 10-37 °C (optimum, 30 °C), pH 6-9 (optimum, pH 7) and with 0-2 % (w/v) NaCl (optimum, 0.5 % NaCl).

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Alcoholic liver disease (ALD) is a major chronic liver disease. Chronic alcohol consumption induces dysbiosis, disruption of gut barrier function, oxidative stress, inflammation, and changes in lipid metabolism, thereby leading to ALD. In this study, we investigated whether the commercial extract Nonitri can ameliorate ALD symptoms through the gut-liver axis.

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Patients with obesity mostly have metabolic syndrome and this can lead to multiple health problems. In the present study, we evaluated the anti-obesity effect of water-soluble red pepper ( L.) leaf extract (PLE) on 3T3-L1 adipocytes and high-fat diet (HFD)-fed mice.

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Although the prevalence of metabolic disorders has progressively increased over the past few decades, metabolic disorders can only be effectively treated with calorie restriction and improved physical activity. Recent research has focused on altering the gut microbiome using prebiotics, probiotics, and postbiotics because various metabolic syndromes are caused by gut microbial dysbiosis. Postbiotics, substances produced or released by microorganism metabolic activities, play an important role in maintaining and restoring host health.

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Gellan gum (GG) is an anionic polysaccharide used as an additive in the food industry. However, the effect of GG on gut microbiota regulation and nonalcoholic fatty liver disease (NAFLD) has not yet been investigated. In vitro fermentation experiments have demonstrated that GG promoted the growth of probiotic strains such as Lactiplantibacillus rhamnosus and Bifidobacterium bifidum, producing metabolites beneficial to gut health.

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Background & Aims: The circadian clock orchestrates ∼24-hour oscillations of gastrointestinal epithelial structure and function that drive diurnal rhythms in gut microbiota. Here, we use experimental and computational approaches in intestinal organoids to reveal reciprocal effects of gut microbial metabolites on epithelial timekeeping by an epigenetic mechanism.

Methods: We cultured enteroids in media supplemented with sterile supernatants from the altered Schaedler Flora (ASF), a defined murine microbiota.

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Two Gram-stain-positive, aerobic, chemoheterotrophic, non-motile, rod-shaped, and yellow-pigmented bacterial strains, designated IMCC34837 and IMCC34838, were isolated from a freshwater stream. Results of 16S rRNA gene-based phylogenetic analyses showed that strains IMCC34837 and IMCC34838 shared 96.3% sequence similarity and were most closely related to Flavihumibacter profundi Chu64-6-1 (99.

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Article Synopsis
  • * Results showed that WERG treatment led to less fat accumulation in both lab cells and mice, as well as improved levels of important fat-related biomarkers in the blood.
  • * Additionally, WERG promoted better gut health by enhancing intestinal barrier function and reducing inflammation, suggesting its potential as a natural anti-obesity treatment.
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Endogenous circadian clocks play a key role in regulating a vast array of biological processes from cell cycle to metabolism, and disruption of circadian rhythms exacerbates a range of human ailments including cardiovascular, metabolic, and gastrointestinal diseases. Determining the state of a patient's circadian rhythms and clock-controlled signaling pathways has important implications for precision and personalized medicine, from improving the diagnosis of circadian-related disorders to optimizing the timing of drug delivery. Patient-derived 3-dimensional enteroids or in vitro "mini gut" is an attractive model uncovering human- and patient-specific circadian target genes that may be critical for personalized medicine.

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The incidence of stress-related type 2 diabetes (stress-T2D), which is aggravated by physiological stress, is increasing annually. The effects of , a key component of probiotics, have been widely studied in diabetes; however, studies on the effects of postbiotics are still limited. Here, we aimed to examine the mechanism through which heat-killed LRCC5314 (HK-LRCC5314) alleviates stress-T2D in a cold-induced stress-T2D C57BL/6 mouse model.

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Bacterial biofilm residing in the oral cavity is closely related to the initiation and persistence of various dental diseases. Previously, we reported the anti-biofilm activity of lipoteichoic acid (Lp.LTA) on a representative dental cariogenic pathogen, .

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