Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules.

Purpose: MHC class I presentation of peptides allows T cells to survey the cytoplasmic protein milieu of host cells. During infection, presentation of self peptides is, in part, replaced by presentation of microbial peptides. However, little is known about the self peptides presented during infection, despite the fact that microbial infections alter host cell gene expression patterns and protein metabolism.

[Psychometric properties of three rating scales for attention deficit hyperactivity disorder in Chilean students].

Objective: To assess, among Chilean students, the reliability and validity of three scales that measure attention deficit hyperactivity disorder (ADHD): the ADHD Rating Scale-IV (ADHD-IV); the scale for evaluating attention deficit disorder with hyperactivity (EDAH); and Spain's version of the ADHD Rating Scale-IV (Spa-ADHD-IV).

Methods: A study of the instruments was conducted with the tutors (n = 612) and teachers (n = 82) of a controlled sample of 640 children 6-11 years of age, who were students attending public schools (n = 228, 35.6% of total), subsidized schools (n = 200, 31.