Publications by authors named "Mirette Edward"
Clin Colorectal Cancer
September 2024
Article Synopsis
- Total neoadjuvant therapy (TNT) for locally advanced rectal cancer (LARC) did not show improved survival compared to standard chemoradiotherapy, and previous trials did not isolate the impacts of various risk factors.
- A retrospective study of 331 patients with T4 and/or N2 rectal adenocarcinoma indicated that 93.4% achieved R0 resection, with a 3-year overall survival rate of 84%, but different high-risk features resulted in varying clinical outcomes.
- The study found that while adjuvant chemotherapy (ACT) improved survival in the overall cohort and N2 subgroup, it did not benefit those with T4 disease; thus, treatment strategies should be tailored
