Renin Genetic Polymorphism in Heart Failure Patients.

Background: Genetic polymorphism of renin-angiotensin-aldosterone system affects the pathogenesis of hypertension (HTN), ischemic heart disease (IHD) and heart failure (HF). The purpose of our study is to analyze A/G renin genetic polymorphism in heart failure patients.

Methods: We investigated renin polymorphism in 83 subjects hospitalized in the Cardiology Department of the Rehabilitation Hospital Cluj-Napoca, using the PCR amplification method.

Drug secondary prevention in postmenopausal women with ischemic heart disease.

Unlabelled: It is known that, in comparison with men, women with cardiovascular disease are undertreated, including drug treatment. This aspect was less studied with respect to drugs used for secondary prevention.

Methods: In an urban Romanian community there was studied a representative sample of 150 postmenopausal women with cardiovascular disease (62.

Correlation between sTNFR-I and other negative prognostic factors in patients with chronic heart failure.

Unlabelled: Tumor necrosis factor (TNF-alpha) and plasma levels of soluble tumor necrosis factor receptor I (sTNFR-I) are increased in patients with heart failure as an expression of chronic inflammation, representing a negative prognostic factor. Anemia and low serum lipid fraction are also negative prognostic factors, whose relationship with sTNFR-I has been less studied.

Methods: The study investigated 54 patients with heart failure, 40 ischemic and 14 nonischemic, 35 males and 19 females, aged 65 +/- 10 years.

The acute effect of ACEI and ARB's upon endothelin in heart failure patients.

Purpose Of The Study: to compare the acute effect of ACEI and ARB's upon the plasmatic endothelin level in heart failure patients.

Methods: There were studied 30 patients with congestive heart failure, III-IV functional NYHA class, that were not under ACEI or ARB's treatment. In all the patients the endothelinl-21 plasmatic level was determined.