Publications by authors named "Mireille Mouroux"
Increase of HIV-1 pro-viral DNA per million peripheral blood mononuclear cells in patients with advanced HIV disease (CD4<200 cells/mm3) receiving interleukin 2 combined with HAART versus HAART alone (ANRS-082 trial).
Constance Delaugerre Karine Gourlain Roland Tubiana Guislaine Carcelain Anne-Geneviève Marcelin Mireille Mouroux
Antivir Ther
June 2003
Article Synopsis
- The study aimed to evaluate the impact of interleukin-2 (IL-2) combined with highly active antiretroviral therapy (HAART) on HIV-1 pro-viral DNA levels in HIV-infected patients with low CD4 counts (less than 200/mm3).
- In a randomized controlled trial involving 70 patients, those receiving IL-2 with HAART demonstrated a significant increase in HIV-1 DNA levels, while those on HAART alone showed a slight decrease.
- Despite the rise in pro-viral DNA, there were no signs of viral resistance or virological failure, indicating that IL-2 might enhance CD4 levels without adversely affecting viral management.