Publications by authors named "Mireia Noguera"
We aimed to determine, using in vivo magnetic resonance, whether maternal depression induced by chronic unpredictable stress (CUS) in the pre-gestational period in female rats would be evidenced by structural or neurometabolic changes in the hippocampal region of the brain. At the same time, appropriate behavioral tests were also administered after a relatively long two-month period of a stress paradigm. The objective of the study was not only to study an animal model of CUS using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (H MRS) focused on the hippocampus, but also to use this technique to verify the effectiveness of mirtazapine antidepressant treatment.
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- Preclinical studies indicate that stress before pregnancy can lead to lasting changes in behavior and mental health in offspring.
- Venlafaxine, a common antidepressant, has not been thoroughly studied for safety during pregnancy and breastfeeding, prompting this investigation into its effects on stressed mother rats and their female pups.
- Findings suggest that maternal stress reduces pup numbers and leads to anxiety-like behavior in offspring, but venlafaxine treatment appears to normalize anxiety levels in adult females, highlighting the need for more clarity on the best antidepressant options for treating maternal depression.