Apalutamide for prostate cancer: Multicentre and multidisciplinary real-world study of 227 patients.

Objective: To evaluate the efficacy and safety of apalutamide prostate cancer compared to the pivotal trials patients and to identify the first subsequent therapy in a real-world setting.

Methods: The study is prospective and observational based on real-world evidence, performed by different medical disciplines and eight academics centres around Barcelona, Spain. It included all patients with metastatic hormone-sensitive prostate cancer (mHSPC) and high-risk non-metastatic castration-resistant prostate cancer (nmCRPC) treated with apalutamide from June 2018 to December 2022.

Technique Description and Outcomes of Robotic Transvaginal-Assisted Living Donor Kidney Transplantation.

Objective: The aim of the study was to describe the surgical technique of totally robotic kidney transplantation with transvaginal insertion and to assess its safety and feasibility.

Methods: It is a prospective analysis of the first 5 cases of robotic kidney transplantation with transvaginal insertion. Robotic-assisted kidney transplantation was performed after transvaginal insertion of a living donor kidney graft.

Renal cell carcinoma and COVID-19 pandemia: Management strategies adapted to current practice.

The COVID-19 pandemic caused by SARS-CoV-2 virus has caused an important health impact that has affected renal cell carcinoma management, among other urology areas. The high cancellation rate of surgeries, including those related to renal cancer, will cause an inevitable healthcare overload and probably a potential negative impact on its oncological outcomes, especially in locally advanced and metastatic renal cancer. Kidney cancer scenarios are quite different depending on their stage, distinguishing mainly between low priority of localized disease or high priority of locally advanced and metastatic under active treatment.

Metastasis of gastric carcinoma simulating a urothelial tumor. Case report and review of the literature.

Objective: To review two cases with the diagnostic suspicion of urinary tract tumor by clinical picture and imaging tests in which pathology of the surgical specimen revealed metastasis of gastric adenocarcinoma.

Methods: 82 and 68 year-old patients with past history of gastric adenocarcinoma that had undergone surgical treatment 6 months and 6 years before urology consultation,respectively. They were diagnosed upper urinary tract tumors by CT scan.

[Surgical aspects of living-donor kidney transplantation].

Laparoscopic living donor nephrectomy has shown less morbidity than the open approach, with less pain and analgesia requirements and allowing a quicker recovery and an earlier return to normal activity. Furthermore, many studies have shown equivalent results between both approaches in terms of graft functions and recipient complications. For these reasons, we can accept laparoscopic kidney living donor nephrectomy as the gold standard surgical technique in these patients.

[Determination of P53 in infiltrative primary bladder tumors as a prognostic factor for understaging].

Objectives: To determine if p53 expression in patients with infiltrative bladder cancer is a prognostic factor on clinical staging and cancer specific survival.

Methods: Immunohistochemical analysis of p53 in 34 patients (33 males and 1 female) undergoing radical cystectomy for infiltrative bladder cancer, with a mean follow-up of 16 months.

Results: p53 overexpression was detected in 18 patients (64%).

Acute bacterial prostatitis: two different sub-categories according to a previous manipulation of the lower urinary tract.

Acute bacterial prostatitis (ABP) (NIH Category I), has not undergone any modification in the update of prostatitis classification. ABP was diagnosed in 614 patients in our centre over 9 years (1993-2001). We analyse the clinical pattern of ABP and the role of bladder outlet obstruction in its etiology, as well as whether two different ABP sub-categories could be defined as a function of a history of previous manipulation of the lower urinary tract.