Publications by authors named "Miranda Odam"
An outbreak of acute hepatitis of unknown aetiology in children was reported in Scotland in April 2022 and has now been identified in 35 countries. Several recent studies have suggested an association with human adenovirus with this outbreak, a virus not commonly associated with hepatitis. Here we report a detailed case-control investigation and find an association between adeno-associated virus 2 (AAV2) infection and host genetics in disease susceptibility.
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- Over 1,000 unexplained pediatric hepatitis cases have been identified globally, with a study focusing on 38 cases and various control groups to understand potential viral causes.
- High levels of adeno-associated virus 2 (AAV2) DNA were found in most cases, while low levels of adenovirus and human herpesvirus 6B were also detected; however, AAV2 appeared infrequently in healthy controls even when they were immunocompromised.
- The study suggests that abnormal replication of AAV2, potentially influenced by other viruses like HAdV and HHV-6B, may be responsible for immune-related liver disease in susceptible children.
Article Synopsis
- - This study focuses on the early detection of patient deterioration in the emergency department (ED) using SNAP40, a wearable device that continuously monitors vital signs and identifies high-risk patients more effectively than standard monitoring methods.
- - The research will examine 250 high-acuity patients aged 16 and over in a teaching hospital's ED, comparing the effectiveness of the SNAP40 device with traditional observation techniques in detecting changes in patients' vital signs.
- - Key outcomes of the study include the speed of detecting patient deterioration and evaluating the experiences of both staff and participants with the SNAP40 device compared to standard monitoring practices.
Kawasaki disease (KD) is a pediatric vasculitis that damages the coronary arteries in 25% of untreated and approximately 5% of treated children. Epidemiologic data suggest that KD is triggered by unidentified infection(s) in genetically susceptible children. To investigate genetic determinants of KD susceptibility, we performed a genome-wide association study (GWAS) in 119 Caucasian KD cases and 135 matched controls with stringent correction for possible admixture, followed by replication in an independent cohort and subsequent fine-mapping, for a total of 893 KD cases plus population and family controls.
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