Publications by authors named "Miranda L Messmer"
Dysfunctional RNA binding protein induced neurodegeneration is attenuated by inhibition of the integrated stress response.
Biochim Biophys Acta Mol Basis Dis
January 2025
Article Synopsis
Article Synopsis
- Research highlights that despite improvements in multiple sclerosis (MS) treatments, neurodegeneration remains a key factor contributing to disability and disease progression, particularly through the dysfunction of the RNA binding protein hnRNP A1 and the presence of smoldering/slowly expanding lesions (SELs).
- The study utilized immunohistochemistry to compare hnRNP A1 pathology in brains of healthy individuals and those with MS, finding a significant correlation between high hnRNP A1 dysfunction and increased neurodegeneration markers in progressive MS cases.
- Findings suggest that hnRNP A1 dysfunction not only plays a role in neurodegeneration but may also be worsened by SELs; notably, some neurons were discovered to be injured but not