HIV transactivation: Stochastic modeling for studying the effects of BET inhibitors on the modulation of P-TEFb levels.

Latency is the major obstacle in eradicating HIV from infected patients. Recent studies have shown that BET protein inhibitors can successfully reverse this latency by inhibiting the binding of BET proteins with positive cellular cofactor P-TEFb. Thus, availability of P-TEFbs plays an important role in HIV transactivation.