Publications by authors named "Miranda Bassel"
Article Synopsis
- The study investigates the link between margin status and local recurrence-free survival (LRFS) in breast cancer patients who had breast-conserving surgery (BCS) after neoadjuvant chemotherapy (NAC).
- It analyzed data from 544 female patients, finding that 41.2% achieved a pathologic complete response (pCR), which resulted in a significantly higher 5-year LRFS compared to those with residual disease.
- The results showed no significant difference in LRFS based on margin width or the number of close margins among patients with residual disease, indicating that margin status may not be as crucial as previously thought.
Introduction: The recent ACOSOG Z11102 trial demonstrated low recurrence rates with breast conserving surgery (BCS) in women with multiple ipsilateral breast cancers (MIBC). Questions remain regarding the oncologic safety of BCS in women with MIBC receiving neoadjuvant chemotherapy (NAC).
Methods: We conducted a retrospective cohort study of adult patients who underwent BCS following NAC for stage I-III breast cancer from 2012 to 2021 at two academic centers.