Reversible Thrombocytopenia of Functional Platelets after Nose-Horned Viper Envenomation Is Induced by a Snaclec.

Profound and transient thrombocytopenia of functional platelets without bleeding was observed in patients envenomed by (). This condition was rapidly reversed by administration of F(ab) fragments of immunoglobulin G targeting the whole venom, leaving platelets fully functional. To investigate the potential role of snake venom C-type lectin-like proteins (snaclecs) in this process, -snaclecs were isolated from the crude venom using different liquid chromatographies.

N-Acetylcysteine Ineffective in Alleviating Hangover from Binge Drinking: A Clinical Study.

Alcohol hangover (veisalgia) is a fairly common phenomenon. The pathogenesis of veisalgia is not understood and treatment has not yet been established. Occasionally, students take N-acetylcysteine (NAC) before binge drinking to alleviate hangover.

Differentiating viral and bacterial infections: A machine learning model based on routine blood test values.

The growing threat of antibiotic resistance necessitates accurate differentiation between bacterial and viral infections for proper antibiotic administration. In this study, a Virus vs. Bacteria machine learning model was developed to distinguish between these infection types using 16 routine blood test results, C-reactive protein concentration (CRP), biological sex, and age.

Association between Prescribing and Intoxication Rates for Selected Psychotropic Drugs: A Longitudinal Observational Study.

Psychotropic prescription drugs are commonly involved in intoxication events. The study's aim was to determine a comparative risk for intoxication in relation to prescribing rates for individual drugs. This was a nationwide observational study in Slovenian adults between 2015 and 2021.

Viper envenomation in Central and Southeastern Europe: a multicentre study.

Introduction: Snakebite incidence varies across Europe. However, there is limited research from Central and Southeastern Europe. These regions are notable for the presence of the common European adder () and the more venomous nose-horned viper ().

Adverse drug reactions in the ambulatory internal patients at the emergency department: Focus on causality assessment and drug-drug interactions.

A non-interventional retrospective study in ambulatory patients was conducted at the emergency department of the Division of internal medicine. In 2 months, 266 suspected adverse drug reactions (ADRs) were identified in 224/3453 patients (6.5 %).

Cytotoxic Effects of Cannabidiol on Neonatal Rat Cortical Neurons and Astrocytes: Potential Danger to Brain Development.

The influence of cannabidiol (CBD) on brain development is inadequately understood. Since CBD is considered a non-intoxicating drug, it has attracted great interest concerning its potential medical applicability, including in pregnant women and children. Here, we elucidated the response of perinatal rat cortical neurons and astrocytes to CBD at submicromolar (0.

COVID-19 diagnosis by routine blood tests using machine learning.

Physicians taking care of patients with COVID-19 have described different changes in routine blood parameters. However, these changes hinder them from performing COVID-19 diagnoses. We constructed a machine learning model for COVID-19 diagnosis that was based and cross-validated on the routine blood tests of 5333 patients with various bacterial and viral infections, and 160 COVID-19-positive patients.

Intravenous Venom-Specific Fab Fragments and Intramuscular Venom-Specific F(ab') Fragments in -Envenomed Patients.

() is the most venomous European viper. The aim of this study was to compare the clinical efficacy and pharmacokinetic values of intravenous venom-specific (paraspecific) Fab fragments (ViperaTAb) and intramuscular venom-specific F(ab') fragments (European viper venom antiserum, also called "Zagreb" antivenom) in -envenomed patients. This was a prospective study of -envenomed patients that were treated intravenously with ViperaTAb or intramuscularly with European viper venom antiserum that was feasible only due to the unique situation of an antivenom shortage.

Comparison of Preclinical Properties of Several Available Antivenoms in the Search for Effective Treatment of and Envenoming.

Snakebites are a relatively rare medical emergency in Europe. In more than half of the annual cases caused by , , and , immunotherapy with animal-derived antivenom is indicated. Among eight products recently identified as available against European medically relevant species, only Zagreb antivenom, Viperfav, and ViperaTAb have been used almost exclusively for decades.

Accidental poisoning with autumn crocus (): a case series.

Introduction: (autumn crocus) is a plant that contains highly toxic alkaloid colchicine. The aim was to evaluate accidental poisoning and assess serum troponin as a prognostic parameter.

Methods: In this study, we retrospectively included all adult patients with a history of accidental ingestion and serum colchicine confirmation during the study period from 2000 to 2019.

Occupational inhalation poisoning with the veterinary antibiotic tiamulin.

Tiamulin is a semisynthetic pleuromutilin diterpene veterinary antibiotic, widely used in farms. We present a case of prolonged QT-interval and ventricular tachyarrhythmia after tiamulin inhalation. A 43-year-old veterinarian without previous medical history was dividing granulated powder of antibiotic gravimetrically without wearing personal protective equipment.

An application of machine learning to haematological diagnosis.

Quick and accurate medical diagnoses are crucial for the successful treatment of diseases. Using machine learning algorithms and based on laboratory blood test results, we have built two models to predict a haematologic disease. One predictive model used all the available blood test parameters and the other used only a reduced set that is usually measured upon patient admittance.

Yellow sac spider (Cheiracanthium punctorium) bites in Slovenia: case series and review.

In Central Europe, reports of human envenomation by Cheiracanthium punctorium, commonly known as the yellow sac spider, are sporadic, despite the fact that this species is widespread in Europe. However, in recent years, C. punctorium has been repeatedly described globally in medical and toxicological literature.

Antivenom for European Vipera species envenoming.

Background: European viper bite is relatively uncommon but can cause serious envenoming, particularly swelling and hemorrhage spreading from limb to trunk that can cause long term disability. Systemic features are relatively mild compared to many other venomous species. Moderate-to-severe envenoming requires antivenom, which is given many hundreds of times each year across the continent.

Comparative analysis of three drug-drug interaction screening systems against probable clinically relevant drug-drug interactions: a prospective cohort study.

Purpose: Drug-drug interaction (DDI) screening systems report potential DDIs. This study aimed to find the prevalence of probable DDI-related adverse drug reactions (ADRs) and compare the clinical usefulness of different DDI screening systems to prevent or warn against these ADRs.

Methods: A prospective cohort study was conducted in patients urgently admitted to medical departments.

Vipera ammodytes bites treated with antivenom ViperaTAb: a case series with pharmacokinetic evaluation.

Context: In clinical practice it is difficult to differentiate between V. berus and V. ammodytes venomous bites.

Occupational transdermal poisoning with synthetic cannabinoid cumyl-PINACA.

Context: Synthetic cannabinoids are getting more popular among young people and illicit manufacturers. We report a case series of occupational transdermal poisoning with synthetic cannabinoids.

Case Details: Three customs inspectors got in contact with a sticky substance with their fingertips because they were not wearing protection gloves and the delivered package was damaged.

Accidental cannabis poisoning in the elderly.

There are two main varieties of Cannabis sativa plant, namely, hemp which is cultivated for fiber and seeds and contains low amounts of psychoactive cannabinoids and the other which is cultivated for the drug cannabis or marijuana. Increasing popularity of hemp food products and alleged beneficial effects of cannabinoids in the drug variety of cannabis might lead to confusion in the lay population and unintentional ingestion of marijuana, as described in this case report. During a workshop on the use of hemp for medicinal purposes, there was a degustation of various hemp food products including also cookies that were brought by one of the attendees.