Publications by authors named "Mirahmadian Mahroo"
Objectives: Vitamin D has potent immunoregulatory features and modulates innate and adaptive immune responses. There is a significant association between intrauterine infection-associated inflammatory responses and pregnancy complications such as abortion and preterm labor. Here, we investigated how 1,25 (OH)2 D3 could modulate inflammatory responses of endometrial cells.
View Article and Find Full Text PDFBackground: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and 2) are involved in blood pressure regulation and single nucleotide polymorphisms (SNPs) of these genes have been linked to preeclampsia. This study intended to assess the association of and genes polymorphism with Iranian preeclamptic women.
Methods: In this case-control study, 148 preeclamptic and 133 pregnant women were selected from the Kosar Hospital, Qazvin, Iran, during 2013-2015.
Background: Toll-like receptor (TLR)-mediated inflammatory processes are supposed to be involved in pathophysiology of spontaneous abortion and preterm labor. Here, we investigated functional responses of human endometrial stromal cells (ESCs) and whole endometrial cells (WECs) to lipopolysaccharide (LPS) and lipoteichoic acid (LTA).
Methods: Endometrial tissues were obtained from 15 cycling women who underwent laparoscopic tubal ligation.
Background: Pre-eclampsia (PE) is a pregnancy associated disorder characterized by hyper-tension and proteinuria. The first 2 stages of PE cause dysfunction in uteroplacental perfusion and oxidative stress while the third stage of PE is due to the release of inflammatory and angiogenic factors, which could lead to maternal endothelial damage and systemic inflammatory response. In this study, we compared the serum levels of tumor necrosis factor-α (TNF-α), interleukin-15 (IL-15), and interleukin-10 (IL-10) in PE and normotensive women.
View Article and Find Full Text PDFArticle Synopsis
- CD200 is overexpressed in AML patients and correlates with increased levels of Foxp3(+) regulatory T cells, which suppress immune responses.
- Blocking the CD200-CD200R interaction leads to reduced levels of immunosuppressive cytokines like IL-10 and TGF-β, while promoting pro-inflammatory cytokines like IL-12 and IFN-γ.
- The findings imply that targeting CD200 could enhance anti-tumor immunity and serve as a possible immunotherapy strategy for acute myeloid leukemia.
Purpose: To compare the aqueous concentration of erythropoietin (EPO) in eyes with primary open-angle (POAG), pseudoexfoliative (PXFG), and neovascular (NVG) glaucoma with age-matched eyes with cataracts, and to correlate its concentration with other factors including age, gender, intraocular pressure (IOP), type of glaucoma, and severity of glaucoma.
Methods: In this prospective non-randomized comparative study, a total of 26 eyes with cataracts (control group) and 92 glaucomatous eyes (POAG, 40 eyes; PXFG, 26 eyes; NVG, 26 eyes) were enrolled. Aqueous samples (0.
Article Synopsis
- RIF (Repeated Implantation Failure) is a significant global health issue affecting patients and healthcare costs.
- Vitamin D(3) was studied for its potential positive effects on cytokine production in endometrial cells from women with RIF compared to healthy fertile women.
- The study found that vitamin D(3) generally reduced cytokine production in both groups, with some exceptions, suggesting that further research on maternal vitamin D(3) levels could be beneficial.
Article Synopsis
- Repeated Implantation Failure (RIF) in assisted reproduction is linked to the cytokine and chemokine levels in the uterine cavity, which impact the implantation process.
- A study compared the cytokine profiles of endometrial tissues from normal fertile women and those with RIF, revealing significant differences in cytokine secretion, particularly in endometrial stromal cells.
- The findings suggest that imbalances in cytokine production may contribute to implantation failure, highlighting the importance of a pro-inflammatory environment for successful implantation.
Analysis of switched memory B cells in patients with IgA deficiency.
Int Arch Allergy Immunol
January 2012
Background: Selective IgA deficiency (SIGAD) is the most common primary antibody deficiency, characterized by significant decreased serum levels of IgA in the presence of normal IgG and IgM. Despite several investigations into the nature of the disease, the exact pathophysiology of SIGAD is still unknown.
Methods: In this study, switched memory B cells (CD19+/CD27+/IgD- cell population) of 28 patients with SIGAD and 28 matched healthy controls were investigated using flow cytometry.
Problem: Considering that certain cytokines may change during pre-eclampsia (PE), because of functional polymorphisms in their genes, our purpose was to determine the association between tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) gene polymorphisms and development of PE.
Method Of Study: The genetic polymorphisms of TNF-alpha and IL-10 was studied by polymerase chain reaction-sequence specific primers in the DNA of peripheral blood cell from 160 patients with PE and 100 healthy pregnant women.
Results: We found a significant difference between TNF-alpha A allele (-308) and G allele (-238) in PE patients compared with those of the control groups.
Problem: To determine whether natural killer (NK) cells cytotoxicity in peripheral blood is altered in patients with a history of recurrent spontaneous abortion (RSA); also, if there is any correlation between cytokine production and NK cytotoxicity.
Method Of Study: In this case-control study, 21 patients with RSA within 24 hr of the last abortion (group I), and 32 pregnants with no history of abortion (group II) were surveyed. NK cell cytotoxicity was evaluated by flow cytometry, and IL-2, IL-10, transforming growth factor beta1 were measured in cell culture supernatant by ELISA method.
Background: Preeclampsia is a major cause of mortality and morbidity and is also a leading cause of preterm birth and intrauterine growth retardation. Several studies have reported abnormal levels of cytokines in women with preeclampsia.
Objectives: To detect serum levels of various cytokines in pregnant women with and without preeclampsia in the third trimester of pregnancy.
Article Synopsis
- Researchers investigated cytokine expression in women with recurrent miscarriage (RM) to see if immune factors play a role in their condition.
- The study involved three groups: women with RM after multiple miscarriages, women who had miscarried but were now past the critical period, and women with no history of miscarriage, with specific attention given to cytokine levels like IL-2 and IL-10.
- Results showed higher levels of IL-2 in women with RM and highlighted that IL-10 is crucial for maintaining a healthy pregnancy.