Publications by authors named "Mira K Semmelroch"
Article Synopsis
- The study investigates the causes of reduced cortical thickness in human epilepsies using brain imaging and gene expression data to understand underlying mechanisms.* -
- Researchers found higher levels of activated microglia and endothelial cells in areas of reduced cortical thickness, both in imaging studies and post-mortem brain tissue from epilepsy patients.* -
- Targeted depletion of activated microglia in a mouse model prevented cortical thinning and neuronal loss, suggesting microglia play a crucial role in these changes, potentially offering new approaches for epilepsy treatment beyond seizure control.*
Objective: To examine cerebral cortex thickness in asymptomatic first-degree relatives of patients with mesial temporal lobe epilepsy (MTLE).
Methods: We investigated 127 asymptomatic first-degree relatives of patients with MTLE due to hippocampal sclerosis (HS) (mean age ± SD = 39.4 ± 13 years) and 203 healthy control individuals (mean age ± SD = 36.
Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n =367), mesial temporal lobe epilepsies with hippocampal sclerosis (MTLE; left, n = 415; right, n = 339), and all other epilepsies in aggregate (n = 1026), and compared to 1727 matched healthy controls.
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