Publications by authors named "Mira Chaplin"
Despite the critical importance of virus disinfection by chlorine, our fundamental understanding of the relative susceptibility of different viruses to chlorine and robust quantitative relationships between virus disinfection rate constants and environmental parameters remains limited. We conducted a systematic review of virus inactivation by free chlorine and used the resulting data set to develop a linear mixed model that estimates chlorine inactivation rate constants for viruses based on experimental conditions. 570 data points were collected in our systematic review, representing 82 viruses over a broad range of environmental conditions.
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- * The newly developed kit-free method called "4S" uses simple and inexpensive materials (sodium chloride, ethanol, and silica) and can recover six times more SARS-CoV-2 RNA than traditional methods.
- * The 4S method also successfully captures other viral controls and maintains RNA stability during storage, allowing for efficient processing of samples and contributing to more effective monitoring of COVID-19 prevalence.
Article Synopsis
- - Wastewater-based epidemiology is used to track COVID-19 by measuring SARS-CoV-2 RNA in wastewater, but current extraction methods need improvement to be faster and more cost-effective.
- - The new "4S" method uses simple and inexpensive ingredients (sodium chloride, ethanol, silica) to extract six times more SARS-CoV-2 RNA compared to older methods, while also detecting other viruses for control.
- - The 4S method is quick (about 3 hours), helps prevent RNA degradation, and aligns with COVID-19 infection data from clinical tests, making it a valuable tool in monitoring the pandemic efficiently and affordably.