Low-level laser therapy, piezocision, or their combination vs. conventional treatment for orthodontic tooth movement : A hierarchical 6-arm split-mouth randomized clinical trial.

Purpose: The use non-invasive or minimally invasive methods to accelerate orthodontic tooth movements (OTM) is desirable. In this regard, low-level laser therapy (LLLT, photobiomodulation) and piezocision are suggested. However, because the efficacies of these methods remain controversial/inconclusive, we investigated and compared these two methods.

Immunomodulatory efficacy of Cousinia thomsonii C.B. Clarke in ameliorating inflammatory cascade expressions.

Ethnopharmacological Relevance: Cousinia thomsonii is traditionally known for treating various diseases including joint pain, swelling, body ache, asthma, dermatitis, cough and arthritis.

Aim Of The Study: This study employs lipopolysaccharide induced inflammatory wistar-rat model to evaluate efficacy of Cousinia thomsonii active-extracts on the expression of crucial inflammatory markers viz. iNOS, PPAR-γ, Rel-A, COX-2 and serum analysis of CRP.

Extent of lymph node dissection and impact on survival in radical cystectomy for advanced bladder cancer.

Purpose Of Review: In patients with muscle invasive bladder cancer (MIBC) or unresectable non-MIBC, radical cystectomy is routinely combined with bilateral pelvic lymph node dissection (LND) owing to the oncological benefits found in recurrence-free survival (RFS), overall survival (OS) and cancer-specific survival (CSS) compared with radical cystectomy alone. However, the optimal anatomic extent of LND is still unclear.

Recent Findings: Retrospective studies were consistent in reporting oncological benefits of extended LND over nonextended LND.

Management of renal cell carcinoma in transplant kidney: a systematic review and meta-analysis.

Introduction: After transplantation, approximately 10% of renal cell carcinomas are detected in graft kidneys. These tumors (gRCC) present surgeons with the difficulty of finding a treatment that guarantees both oncological clearance and maintenance of function. We conducted a systematic review and an individual patient data meta-analysis on the oncology, safety and functional outcomes of the available treatments for gRCC.

Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE.

Aims: To evaluate the association between chronic treatment with betablockers (BB) and the severity of decompensation and short-term outcomes of patients with acute heart failure (AHF).

Methods And Results: We consecutively included all patients presenting with AHF to 45 Spanish emergency departments (ED) during six different time-periods between 2007 and 2018. Patients were stratified according to whether they were on chronic treatment with BB at the time of ED consultation.

A Dual Functional 2D MOF Exhibiting Rare Photosalient Effect as well as Selective Pd(II) Sensing in Aqueous Medium.

A Zn(II) based two-dimensional metal-organic framework (2D MOF) [Zn(suc)(4-nvp)] () [Hsuc = succinic acid and 4-nvp = 4-(1-naphthylvinyl)pyridine] exhibits a "photosalient effect" under UV light as well as sunlight along with the release of a stereoselective cyclobutane ligand, 1,3-bis(4'-pyridyl)-2,4-bis(naphthyl)cyclobutane (-4-pncb). Photolysis of in situ generated MOF in solution also leads to the formation of -4-pncb crystals. Interestingly, compound shows a high selectivity for Pd(II) sensing in aqueous medium.

Laser Assisted Surgical and Orthodontic Treatment of a Dilacerated Impacted Maxillary Incisor: A Case Report.

Impaction of the anterior teeth, which is less frequent in central incisors, can cause serious esthetic and subsequent psychological problems for patients during the mixed dentition period. Traumatic injury to deciduous teeth is the most common etiologic factor. Thus, treatment of maxillary incisor impaction is highly important.

Comparative transcriptomics unravels new genes imparting scab resistance in apple (Malus x domestica Borkh.).

Apple scab is caused by an ascomycete fungus, Venturia inaequalis (Cke.) Wint., which is one of the most severe disease of apple (Malus × Domestica Borkh.

Manipulation and exploitation of host immune system by pathogenic for its advantage.

() can become a long-term infection by evading the host immune response. Coevolution of with humans has resulted in its ability to hijack the host's immune systems in a variety of ways. So far, every defense strategy is essentially dependent on a subtle balance that, if shifted, can promote proliferation in the host, resulting in disease progression.

Recent advances in biodecolorization and biodegradation of environmental threatening textile finishing dyes.

Organic nature of dyes and their commercially made products are widely utilized in many industries including paper, cosmetics, pharmaceuticals, photography, petroleum as well as in textile manufacturing. The textile industry being the top most consumer of a large variety of dyes during various unit processes operation generates substantial amount of wastewater; hence, nominated as "Major Polluter of Potable Water". The direct discharge of such effluents into environment poses serious threats to the functioning of biotic communities of natural ecosystems.

Adapalene and Doxorubicin Synergistically Promote Apoptosis of TNBC Cells by Hyperactivation of the ERK1/2 Pathway Through ROS Induction.

Doxorubicin is a commonly used chemotherapeutic agent to treat several malignancies, including aggressive tumors like triple-negative breast cancer. It has a limited therapeutic index owing to its extreme toxicity and the emergence of drug resistance. As a result, there is a pressing need to find innovative drugs that enhance the effectiveness of doxorubicin while minimizing its toxicity.

Expression patterns and therapeutic implications of CDK4 across multiple carcinomas: a molecular docking and MD simulation study.

The CDKs are known to play a critical role in cell cycle regulation process. Among the different groups of CDKs, CDK4 overexpression/hyperactivation is found to be present in many cancers and a specific CDK4 inhibitor, palbociclib has been recently approved by the FDA against breast cancer. However, the treatment with palbociclib has shown many associated toxicities such as-anemia, thrombocytopenia, neutropenia, and febrile neutropenia and more.

Molecular docking analysis and evaluation of the antimicrobial properties of the constituents of Geranium wallichianum D. Don ex Sweet from Kashmir Himalaya.

Geranium wallichianum D. Don ex Sweet is a well-known medicinal plant in Kashmir Himalya. The evidence for its modern medicinal applications remains majorly unexplored.

Electronic Cigarettes: Are They Smoking Cessation Aids or Health Hazards?

The US Food and Drug Administration (FDA) recently approved the marketing of an electronic cigarette (e-cig) brand called Vuse (RJ Reynolds Vapor Company, US) to help aid in smoking cessation for adult smokers. It was believed that the consumption of traditional cigarettes and their harmful effects would be reduced given the availability of newer e-cigarettes. However, adolescent use of tobacco and nicotine products rather increased with the availability of the same e-cigarettes, and the FDA-approved market boom only worsened this problem.

Structure and surface analyses of a newly synthesized acyl thiourea derivative along with its and investigations for RNR, DNA binding, urease inhibition and radical scavenging activities.

-((4-Acetylphenyl)carbamothioyl)-2,4-dichlorobenzamide (4) was synthesized by the treatment of 2,4-dichlorobenzoyl chloride with potassium thiocyanate in a 1 : 1 molar ratio in dry acetone to afford the 2,4-dichlorobenzoyl isothiocyanate which on reaction with acetyl aniline furnished (4) in good yield and high purity. The compound was confirmed by FTIR, H-NMR, and C-NMR and single crystal X-ray diffraction studies. The planar rings were situated at a dihedral angle of 33.

Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors.

Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involved in cell cycle maintenance. Given that overexpression of CDK1 has been associated with cancer, CDK1 inhibitors may restore equilibrium to the skewed cell cycle system and operate as an effective therapeutic drug.

The Well-Being of Healthcare Workers During the COVID-19 Pandemic: A Narrative Review.

The coronavirus disease 2019 (COVID-19) pandemic has turned into a global healthcare challenge, causing significant morbidity and mortality.Healthcare workers (HCWs) who are on the frontline of the COVID-19 outbreak response face an increased risk of contracting the disease. Some common challenges encountered by HCWs include exposure to the pathogen, psychological distress, and long working hours.

Selecting the Best Candidates for Cisplatin-based Adjuvant Chemotherapy After Radical Cystectomy Among Patients with pN+ Bladder Cancer.

A trend towards greater benefit from adjuvant chemotherapy (ACT) in pN+ bladder cancer (BCa) has been observed in multiple randomized controlled trials. However, it is still unclear which patients might benefit the most from this approach. We retrospectively analyzed a multicenter cohort of 1381 patients with pTany pN1-3 cM0 R0 urothelial BCa treated with radical cystectomy (RC) with or without cisplatin-based ACT.

Global quality of life in breast cancer: systematic review and meta-analysis.

Background: Breast cancer (BC) is the most common cancer among women worldwide. We conducted a systematic review and meta-analysis to cover the existing research gap and contribute to existing knowledge to provide both researchers and clinicians with a better profile on the topic and consequently help improve the quality of life (QoL) of patients with BC.

Methods: A comprehensive review of original articles published in English from January 2000 to October 2021 from databases including Embase, Scopus, PubMed and Web of Science was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.

The prospective study of change of perception of postgraduate students on objective structured clinical examination in burns and plastic surgery.

Background: In this study, we attempted to assess the change of perception of postgraduate students on objective structured clinical examination (OSCE) in burns and plastic surgery after first five OSCE.

Methods: A prevalidated feedback questionnaire was used to assess and score the perception of postgraduate students on OSCE in burns and plastic surgery. The opinion of postgraduate students on the feedback questionnaire after first and fifth assessment tests based on OSCE was analyzed.