Publications by authors named "Miquel Angel Pericas"
Selective sigma-1 (sigma1) receptor antagonists: emerging target for the treatment of neuropathic pain.
Cent Nerv Syst Agents Med Chem
September 2009
A large number of therapeutic roles have been proposed for sigma(1) receptors but the involvement of sigma(1) receptor in non-acute pain had not been well explored up to now. sigma(1) receptor knock-out mice became available offering us the possibility to study the role of sigma(1) receptor in nociception, particularly in models where central sensitization processes play a significant role. Given the attractive therapeutic potential, we have developed a chemical program aimed at the discovery of novel and selective sigma(1) ligands.
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- New families of enantiopure bis(oxazolines) with distinct stereochemistry (4,5-trans and 4,5-cis) were synthesized with high efficiency.
- The trans oxazoline derivatives formed eta(3)-allyl palladium complexes that were effective in catalyzing allylic alkylation reactions with high enantioselectivity, reaching up to 96%.
- NMR studies revealed the presence of different isomer forms in the palladium intermediates, highlighting a novel case of isomerism in Pd allylic complexes with malonic acid-derived bis(oxazolines).