Publications by authors named "Mio Yumura"
Article Synopsis
- Accurate estimation of tumor mutational burden (TMB) can be improved by including non-coding regions in gene panel assays, which are often overlooked in current calculations that only consider coding regions.
- This study tested the OncoGuide NCC Oncopanel System (NOP) and found that using both coding and non-coding regions (NOP-overall) significantly increased agreement with TMB status compared to using only coding regions (NOP-coding).
- Results showed a higher overall percent agreement (OPA) and smaller mean difference in TMB values when including non-coding regions, underlining their importance for precise TMB estimates, especially in smaller panels.
Construction of a complex artificial self-replication system is challenging in the field of in vitro synthetic biology. Recently, we developed a translation-coupled RNA replication system, wherein an artificial genomic RNA replicates with the Qβ RNA replicase gene encoded on itself. The challenge is to introduce additional genes into the RNA to develop a complex system that mimics natural living systems.
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