Publications by authors named "Minzi Zheng"
Strain-level genomic analysis of serotype, genotype and virulence gene composition of group B streptococcus.
Front Cell Infect Microbiol
November 2024
Introduction: GBS (group B streptococcus) is an opportunistic pathogen that can colonize healthy individuals but presents significant challenges in clinical obstetrics and gynecology, as it can cause miscarriage, preterm birth, and invasive infections in newborns. To develop specific and personalized preventative strategies, a better understanding of the epidemiological characteristics and pathogenic features of GBS is essential.
Methods: We conducted a comprehensive strain-level genomic analysis of GBS, examining serotype and genotype distributions, as well as the composition and correlations of virulence genes using the blastn-short mode of the BLAST program(v2.
Article Synopsis
- Vaginitis is a common issue affecting about 75% of women, with recurrent cases often due to resistance to current antimicrobial treatments, sparking the need for new drug development.
- A new biological bacteriostatic agent (BBA) was tested for its effectiveness against various vaginitis-causing bacteria and its safety in female mice, showing promising antibacterial effects and safety.
- Both BBA and a 70% gel form of BBA significantly reduced pathogen growth and inflammation in mice with vaginitis, with the gel demonstrating superior results compared to BBA alone.
Purpose: The purpose of this study was to overcome the clinical defects of 7-ethyl-10-hydroxycamptothecin (SN-38) and explore its characteristics and antitumor effects.
Materials And Methods: An amorphous solid dispersion of SN-38 with disodium glycyrrhizin (NaGA) was prepared by mechanical ball milling (NaGA/SN-38-BM). Moreover, an untreated mixture of NaGA and SN-38 (NaGA/SN-38-UM), a pure drug SN-38, was prepared for comparison with NaGA/SN-38-BM.