Coffee intake, plasma caffeine levels, and diabetic microvascular complications: A Mendelian randomization study.

Background And Aim: Diabetic microvascular complications pose significant health challenges for individuals. The influence of modifiable lifestyle factors, such as coffee intake, on these complications has not been conclusively determined, highlighting the need for a causality assessment.

Methods And Results: Utilizing Mendelian randomization (MR), this study explored the causal links between coffee intake, plasma caffeine levels, and diabetic microvascular complications using data from FinnGen.

FishTEDB 2.0: an update fish transposable element (TE) database with new functions to facilitate TE research.

We launched the initial version of FishTEDB in 2018, which aimed to establish an open-source, user-friendly, data-rich transposable element (TE) database. Over the past 5 years, FishTEDB 1.0 has gained approximately 10 000 users, accumulating more than 450 000 interactions.

Transient effect of suction on the retinal neurovasculature in myopic patients after small-incision lenticule extraction.

Purpose: To characterize retinal neurovasculature changes after small-incision lenticule extraction (SMILE) in myopic patients.

Setting: Ophthalmic Center, the Second Affiliated Hospital of Guangzhou Medical University, China.

Design: Prospective interventional study.

Enhanced functional properties of human limbal stem cells by inhibition of the miR-31/FIH-1/P21 axis.

Objective: On the basis of the functional roles of the embryonic stem cell niche (ESCN) in the human limbal stem cells (LSCs), we proposed to explore the potential roles of microRNAs in regulating the self-renewal and differentiation of LSCs cultured in the ESCN.

Methods: The LSCs were cultured in different media, either in CnT-20 media or in CnT-20 + 20% ES culture supernatant (ESC-CM). The LSCs cultured in ESC-CM were then transfected with microRNA-31 (miR-31) mimic or antago-31.