Implementation path of dual-carbon in Xiguan historical and cultural district of Guangzhou：A case study on changhua street.

In the context of ecological civilization construction, cities are the main source of greenhouse gas emissions and thus they are key areas for dual-carbon construction. The dual-carbon community is the basic unit of the dual-carbon city and is essential for the promotion and construction of beautiful China. Guangzhou, as a historical and cultural city, is actively exploring the micro-renewal path of historical and cultural neighborhoods.

Methylthiophenyl- and Methylthiobiphenyl-Substituted AB Cocorroles: Modulating Electrocatalyzed Hydrogen Evolution Reactions on Surface-Modified Gold Electrodes.

Four AB-type Cocorroles () with electron-donating/withdrawing substituents at the A -aryl substituents and a 4-(methylthio)phenyl ring at the B position have been synthesized and characterized, along with a series of -extended Cocorroles (-) with 4'-(methylthio)biphenyl moieties. The electronic structures and structure-property relationships of the dyes have been analyzed by comparing their redox and optical properties to trends predicted in density functional theory calculations. Au electrodes surface-modified with - and - are highly efficient catalysts for electrocatalyzed hydrogen evolution reactions, and the electrocatalytic properties can be readily modulated by fine-tuning the electronic structure of the Cocorrole and the distance between the "Au-S" bond and Co center.

Construction of DCM-based NIR fluorescent probe for visualization detection of HS in solution and nanofibrous film.

Hydrogen sulfide (HS) played crucial roles in biological processes and daily life, and the abnormal level of HS was associated with many physiological processes. In this paper, we designed and developed a dicyanomethylene-4H-chromene (DCM)-based near-infrared (NIR) fluorescent probe DCM-NO guided by theoretical calculation. The probe displayed excellent selectivity towards HS with a fast response time (3 min) and low detection limit (fluorescence 25.

Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in bipolar disorder with current major depressive episode patients.

Background: The microbiome-gut-brain axis, especially the microbial tryptophan biosynthesis and metabolism pathway (MiTBamp), is closely connected to bipolar disorder with current major depressive episode (BPD).

Methods: We performed shotgun metagenomics sequencing (SMS) of faecal samples from 25 BPD patients and 28 healthy controls (HCs). Except for the microbiota taxa and MiTBamp analyses, we also built a classification model using the Random Forests (RF) and Boruta algorithm to find the microbial biomarkers for BPD.

Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression.

Background: Electroconvulsive therapy (ECT) is the most rapid and effective treatment for patients with depression, ECT can achieve remarkable antidepressant effects in the initial 3-4 sessions, but significant side effects limit its use. However, recent low-charge electrotherapy (LCE) studies have demonstrated antidepressant or antipsychotic effects with significantly fewer side effects. The aim of this study is to propose a novel two-step charge set strategy for ECT treatment, referred to as Hybrid-ECT, to decrease side effects by using a low charge while preserving treatment efficacy.

Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in major depressive disorder patients.

Background: The microbiota-gut-brain axis, especially the microbial tryptophan (Trp) biosynthesis and metabolism pathway (MiTBamp), may play a critical role in the pathogenesis of major depressive disorder (MDD). However, studies on the MiTBamp in MDD are lacking. The aim of the present study was to analyze the gut microbiota composition and the MiTBamp in MDD patients.

Low-charge electrotherapy for patients with schizophrenia: A double-blind, randomised controlled pilot clinical trial.

A double-blind, randomised controlled pilot clinical trial was conducted to assess the potential effectiveness and safety of low-charge electrotherapy (LCE) for patients with schizophrenia. Bitemporal LCE (approximately 2.8 Joules) was administered three times a week.

Iron(iii)porphyrin electrocatalyzed enantioselective carbon-chloride bond cleavage of hexachlorocyclohexanes (HCHs): combined experimental investigation and theoretical calculations.

Enantioselective electrocatalysis of α-, β-, γ- and δ-hexachlorocyclohexanes (HCHs) by tetrakis-pentafluorophenyl-Fe(iii)porphyrin is described. The first example of the combined use of electrochemical measurements and theoretical calculations to determine the mechanism of the enantioselective C-Cl bond cleavage of the electrocatalysis is reported. The electrochemical measurements demonstrate that the reactivity of the HCHs follows the order γ-HCH > α-HCH > δ-HCH > β-HCH.

Regioselective Oxidative Ring Cleavage of a Phlorin Analogue: An Approach for Synthesizing Linear Tetrapyrroles.

Oxidation of neo-N-confused phlorin 1 with excessive FeCl leads to regioselective ring opening, generating three linear tetrapyrroles, i.e., (10 Z,15 Z)-biladienone 2, (10 Z,15 E)-biladienone 3, and 19-methoxy (10 Z,15 E)-biladiene 4 with an overall yield of 88%.

Cu(iii)triarylcorroles with asymmetric push-pull meso-substitutions: tunable molecular electrochemically catalyzed hydrogen evolution.

The synthesis of four low symmetry AB type Cu(iii)triarylcorroles with meso-aryl substituents that provide electron donating (push) and withdrawing (pull) properties is reported, along with their structural characterization by NMR spectroscopy and X-ray crystallography. An analysis of the structure-property relationships in the optical and redox properties has been carried out by comparing their optical spectroscopy, electrochemistry, and spectroelectrochemistry to trends predicted in DFT and TD-DFT calculations. The results demonstrate that AB type Cu(iii)triarylcorroles are highly efficient catalysts for electrocatalyzed hydrogen evolution reactions (HERs) and that their reactivity can be modulated by changing the nature of the B-position meso-substituent.

Flexible Metal-Porphyrin Dimers (M=Mn Cl, Co , Ni , Cu ): Synthesis, Spectroscopy, Electrochemistry, Spectroelectrochemistry, and Theoretical Calculations.

Four metalloporphyrin dimers linked by bridging amide-bonded xanthene moieties and that contain either Mn , Co , Ni , or Cu metal centers were synthesized. Various spectroscopic, electrochemical, and spectroelectrochemical methods were used to study trends in their properties. Their electronic structure and optical properties were analyzed through a comparison of the electronic absorption and magnetic circular dichroism (MCD) spectral data with the results of time-dependent (TD)-DFT calculations.

Neo-N-confused Phlorins and Phlorinone: Rational Synthesis and Tunable Properties.

By the acid-catalyzed [2 + 2] condensation, an unprecedented neo-N-confused phlorin (neo-NCphlorin 1) was successfully synthesized. By treating 1 with N-chlorosuccinimide, the corresponding chloro-substituted neo-NCphlorin (1-Cl) was obtained. The oxidization of 1 with FeCl afforded the neo-N-confused phlorinone (neo-NCphlorinone 2), which bears a relatively coplanar conformation, different from the highly distorted ones observed for 1 and 1-Cl.

Tetra- and Octapyrroles Synthesized from Confusion and Fusion Approaches.

By oxidation of an alternately N-confused bilane in CHCl, a C-N fused tetrapyrrin was synthesized that bears a 5.5.5-tricyclic ring generated from an intramolecular C-N linkage.

Lipophilic M(α,α'-OC5H11)8phthalocyanines (M = H2 and Ni(II)): synthesis, electronic structure, and their utility for highly efficient carbonyl reductions.

A lipophilic and electron-rich phthalocyanine (α,α'-n-OC5H11)8-H2Pc and its nickel(ii) complex (α,α'-n-OC5H11)8-Ni(ii)Pc have been synthesized and characterized. Detailed analyses of the electronic structure were carried out by spectroscopy, electrochemistry, spectroelectrochemistry, and TD-DFT calculations. A series of experiments demonstrate that the (α,α'-n-OC5H11)8-Ni(ii)Pc complex can be used as a catalyst for highly efficient carbonyl reductions.

Effect of bone morphogenetic protein 7 on differentiation of adipose derived mesenchymal stem cells into brown adipocytes in rats.

Objective: To evaluate the effect of bone morphogenetic protein(BMP7)on the differentiation of adipose derived mesenchymal stem cells(AD-MSCs)isolated from different adipose tissues into brown adipocytes in rats.

Methods: Primary AD-MSCs were isolated from rate interscapular brown adipose tissue(iBAT),inguinal subcutaneous white adipose tissue(sWAT),and epididymal white adipose tissue(eWAT),respectively,and then cultivated in vitro. Differentiation of AD-MSCs into brown adipocytes was induced by BMP7.

[Preparation of and study on magnetic resonance imaging performance of metal porphyrin modified by low molecular weight chitosan].

The functional complex Mn-TCPP-CS20 as a potential magnetic resonance imaging (MRI) contrast agent was synthesized through tetra(4-carboxyphenyl) Mn(II)-porphyrin (Mn-TCPP) modified by CS20, which was low degree of polymerization and narrow distribution. The results showed that Mn-TCPP-CS20 had good water-solubility and structural stability. The chemical structures of the products were characterized with Fourier transform infrared spectra (FTIR), UV-Vis spectra, mass spectrum (MS) and inductively coupled plasma atomic emission spectrometry (ICP-AES).

Genetic polymorphism of ITGA2 C807T can increase the risk of ischemic stroke.

Background: The role of genetic variants in the pathogenesis of stroke has not been fully elucidated. Several studies have been examined the association of the Integrin alpha2 (ITGA2) gene-C807T (rs1126643) polymorphism with ischemic stroke susceptibility. However, the results of these studies are inconsistent.

Trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland china from 1979 to 2012.

Diabetes mellitus (DM) is one of the primary causes of premature death and disability worldwide. We performed a systematic review and meta-analysis of the published literature regarding the trends in prevalence, awareness, treatment, and control of diabetes mellitus in mainland China. PUBMED, EMBASE, Chinese Biomedical Database, China National Infrastructure database, Chinese Wan Fang database, and Chongqing VIP database were searched.

Synthesis of reduced graphene oxide/CeO2 nanocomposites and their photocatalytic properties.

With a unique structure and extraordinary properties, graphene has attracted tremendous attention in the preparation of graphene-based composites for various applications. In this study, two different strategies, including in situ growth and a self-assembly approach, have been developed to load CeO2 nanoparticles onto reduced graphene oxide (RGO) nanosheets. The microstructure and morphology of the as-synthesized RGO/CeO2 nanocomposites were investigated by x-ray diffraction, Raman spectroscopy and transmission electron microscopy.

In situ growth of Ni(x)Co(100-x) nanoparticles on reduced graphene oxide nanosheets and their magnetic and catalytic properties.

Ni(x)Co(100-x) (x = 0, 25, 50, 75, and 100) nanoparticles were uniformly in situ grown on reduced graphene oxide (RGO) nanosheets by a coreduction process for the first time. The as-synthesized products were characterized by X-ray powder diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), inductively coupled plasma optical emission spectrometry (ICP-OES), and transmission electron microscopy (TEM). It was found that RGO nanosheets can effectively prevent the aggregation of Ni(x)Co(100-x) nanoparticles.